• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Public Health >Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature
【24h】

Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature

机译：肾移植患者药物遗传学检测的经济评价：文献综述

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs. Nowadays, due to restrictive health resources, the question arises whether routine pharmacogenetic analyses should be done in the renal transplant recipients or not. The aim of this literature review was to present the up-to-date information considering the economic feasibility of pharmacogenetic testing in patients subjected to renal transplantation. The organization United Network for Organ Sharing in the US estimated that total costs per renal transplant concerning these analyses were $334,300 in 2014. Pharmacogenetic testing prior to treatment initiation could be helpful to predict and assess treatment response and the risks for adverse drug reactions. This kind of testing before treatment initiation seems to be one of the most promising applications of pharmacokinetics. Although pharmacogenetic tests were found to be a cost-effective or cost-saving strategy in many cases, some authors represent another opinion. However, if the real costs of renal transplantation are recognized, the application of these tests in the standard daily practice could be considered more realistic, which additionally emphasizes the importance of future studies assessing their cost effectiveness.
机译：肾移植是终末期肾衰竭患者的首选治疗方法。遗传因素尤其可以影响对免疫抑制药物反应的变异性。如今，由于健康资源有限，问题在于是否应在肾移植接受者中进行常规药物遗传学分析。这篇文献综述的目的是提供考虑到进行肾移植患者药物遗传学检测的经济可行性的最新信息。美国组织器官共享网络联合会估计，这些分析在2014年的每次肾脏移植总费用为334,300美元。治疗开始前的药物遗传学测试可能有助于预测和评估治疗反应以及药物不良反应的风险。在治疗开始之前进行这种测试似乎是药代动力学最有前途的应用之一。尽管在许多情况下发现药物遗传学检测是一种具有成本效益或节省成本的策略，但一些作者还是提出了另一种观点。但是，如果认识到肾移植的实际成本，则可以认为这些测试在标准的日常实践中的应用更为现实，这进一步强调了评估其成本效益的未来研究的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号