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Diffusion-Exchange Weighted Imaging

机译:扩散交换加权成像

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A method has been developed whereby diffusion and exchange in micro cellular structures in the human brain are correlated to produce a new type of image contrast leading to determination of water exchange rates in vivo. The diffusion method relies on differential apparent diffusion coefficients as detectable nuclei exchange between adjacent compartments marked with different apparent diffusion coefficient values (e.g. intra- and extra-cellular compartments). A new pulse sequence was developed, and used to calculate water intra/extra mean residence times in brain, and the signal dependence on various experimental parameters was analysed. The method was tested in vivo at 3T field strength and produced 160 ms and 550 ms for extra-cellular and intra-cellular mean residence times, respectively.
机译:已经开发了一种方法,通过该方法可以使人脑中的微细胞结构的扩散和交换相互关联,以产生一种新型的图像对比度,从而确定体内的水交换速率。扩散方法依赖于不同的表观扩散系数,因为在标有不同表观扩散系数值(例如细胞内和细胞外的隔室)的相邻隔室之间可检测到的原子核交换。开发了一种新的脉冲序列,并将其用于计算水在大脑中的内部/外部平均停留时间,并分析了信号对各种实验参数的依赖性。该方法在3T场强度下进行了体内测试,并分别产生了160 ms和550 ms的细胞外和细胞内平均停留时间。

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