Iron Oxide as an MRI Contrast Agent for Cell Tracking

Daniel J. Korchinski; May Taha; Runze Yang; Nabeela Nathoo; Jeff F. Dunn

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Iron Oxide as an MRI Contrast Agent for Cell Tracking

机译：氧化铁作为用于细胞跟踪的MRI造影剂

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Iron oxide contrast agents have been combined with magnetic resonance imaging for cell tracking. In this review, we discuss coating properties and provide an overview of ex vivo and in vivo labeling of different cell types, including stem cells, red blood cells, and monocytes/macrophages. Furthermore, we provide examples of applications of cell tracking with iron contrast agents in stroke, multiple sclerosis, cancer, arteriovenous malformations, and aortic and cerebral aneurysms. Attempts at quantifying iron oxide concentrations and other vascular properties are examined. We advise on designing studies using iron contrast agents including methods for validation.

机译：氧化铁造影剂已与磁共振成像结合用于细胞跟踪。在这篇综述中，我们讨论了涂层的特性，并概述了不同细胞类型（包括干细胞，红细胞和单核细胞/巨噬细胞）的离体和体内标记。此外，我们提供了在中风，多发性硬化，癌症，动静脉畸形以及主动脉和脑动脉瘤中使用铁对比剂进行细胞跟踪的应用实例。检查了量化氧化铁浓度和其他血管性质的尝试。我们建议设计使用铁对比剂的研究，包括验证方法。

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《Magnetic Resonance Insights》 |2015年第1期|共15页
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Daniel J. Korchinski; May Taha; Runze Yang; Nabeela Nathoo; Jeff F. Dunn;
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中图分类临床医学;
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Iron Oxide as an MRI Contrast Agent for Cell Tracking

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