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首页> 外文期刊>Frontiers in Aging Neuroscience >Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder
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Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder

机译：通过认知和体育相结合的训练获得认知：训练剂量和神经认知障碍严重程度的作用

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Physical as well as cognitive training interventions improve specific cognitive functions but effects barely generalize on global cognition. Combined physical and cognitive training may overcome this shortcoming as physical training may facilitate the neuroplastic potential which, in turn, may be guided by cognitive training. This study aimed at investigating the benefits of combined training on global cognition while assessing the effect of training dosage and exploring the role of several potential effect modifiers. In this multi-center study, 322 older adults with or without neurocognitive disorders (NCDs) were allocated to a computerized, game-based, combined physical and cognitive training group ( n = 237) or a passive control group ( n = 85). Training group participants were allocated to different training dosages ranging from 24 to 110 potential sessions. In a pre-post-test design, global cognition was assessed by averaging standardized performance in working memory, episodic memory and executive function tests. The intervention group increased in global cognition compared to the control group, p = 0.002, Cohen’s d = 0.31. Exploratory analysis revealed a trend for less benefits in participants with more severe NCD, p = 0.08 (cognitively healthy: d = 0.54; mild cognitive impairment: d = 0.19; dementia: d = 0.04). In participants without dementia, we found a dose-response effect of the potential number and of the completed number of training sessions on global cognition, p = 0.008 and p = 0.04, respectively. The results indicate that combined physical and cognitive training improves global cognition in a dose-responsive manner but these benefits may be less pronounced in older adults with more severe NCD. The long-lasting impact of combined training on the incidence and trajectory of NCDs in relation to its severity should be assessed in future long-term trials.
机译：身体和认知训练干预措施可改善特定的认知功能，但对整体认知的影响几乎没有普遍性。物理和认知训练相结合可以克服这一缺点，因为体育锻炼可以促进神经塑形的潜力，而神经塑形的潜力又可以由认知训练来指导。这项研究旨在调查综合培训对整体认知的好处，同时评估培训剂量的效果并探索几种潜在效果修饰符的作用。在这项多中心研究中，将322名有或没有神经认知障碍（NCD）的老年人分配到计算机化，基于游戏的，基于身体和认知的综合训练组（n = 237）或被动对照组（n = 85）。培训组的参与者被分配了不同的培训剂量，范围从24到110个潜在课程。在测试前的设计中，通过对工作记忆，情景记忆和执行功能测试中标准化表现的平均来评估整体认知。与对照组相比，干预组的整体认知能力有所提高，p = 0.002，Cohen d = 0.31。探索性分析显示，患有较严重的NCD的受试者获益减少的趋势，p = 0.08（认知健康：d = 0.54;轻度认知障碍：d = 0.19;痴呆：d = 0.04）。在没有痴呆症的参与者中，我们发现潜在次数和完成的训练次数对整体认知的剂量反应效应，分别为p = 0.008和p = 0.04。结果表明，体育锻炼和认知训练相结合，可以以剂量反应的方式改善整体认知，但这些益处在患有严重NCD的老年人中可能并不明显。应在以后的长期试验中评估联合培训对NCD的发生率和轨迹及其严重程度的长期影响。

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