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首页> 外文期刊>Frontiers in Neuropharmacology >Factors Associated With Response and Resistance to Cognitive Remediation in Schizophrenia: A Critical Review
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Factors Associated With Response and Resistance to Cognitive Remediation in Schizophrenia: A Critical Review

机译：与精神分裂症的反应和对认知补救的抵抗相关的因素：一项重要的审查。

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Cognitive impairment is a central feature of schizophrenia and has shown to play a crucial role in the psychosocial function of the disorder. Over the past few years, several cognitive remediation (CR) interventions have been developed for schizophrenia, whose effectiveness has also been widely demonstrated by systematic reviews and meta-analysis studies. Despite these evidences, many questions remain open. In particular, the identification of CR response predictors in patients with schizophrenia is still a topic with equivocal findings and only a few studies have looked for the relationship between CR response or resistance and the biological, socio-demographic, clinical and cognitive features in schizophrenia. The current knowledge on positive or negative response predictors to CR treatment in schizophrenia include: age, duration of illness, premorbid adjustment, baseline cognitive performance, intrinsic motivation, hostility, disorganized symptoms, neurobiological reserve, genetic polymorphisms, the amounts of antipsychotics, the type of CR, etc. The aim of this review is to identify neurobiological, psychopathological, cognitive and functional predictors of CR response or resistance in schizophrenia, taking into account both cognitive and functional outcome measures. The information obtained could be very useful in planning integrated and personalized interventions, also with a better use of the available resources.
机译：认知障碍是精神分裂症的主要特征，并且已显示在该障碍的社会心理功能中起关键作用。在过去的几年中，已经为精神分裂症开发了几种认知矫正（CR）干预措施，其有效性也已通过系统的综述和荟萃分析研究得到了广泛证明。尽管有这些证据，许多问题仍然存在。特别是，在精神分裂症患者中确定CR反应预测因子仍然是一个模棱两可的发现，只有少数研究寻找了CR反应或耐药与精神分裂症的生物学，社会人口统计学，临床和认知特征之间的关系。当前关于精神分裂症CR治疗的阳性或阴性反应预测因子的知识包括：年龄，疾病持续时间，病前调整，基线认知表现，内在动机，敌意，无序症状，神经生物学储备，遗传多态性，抗精神病药的数量，类型本文旨在探讨精神分裂症中CR反应或抵抗的神经生物学，心理病理学，认知和功能预测因素，同时考虑认知和功能结局指标。获得的信息在规划综合性和个性化干预措施时也可能非常有用，而且可以更好地利用可用资源。

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