A Method to Monitor Dutasteride in Rat Plasma Using Liquid-Liquid Extraction and Multiple Reaction Monitoring: Comparisons and Validation

Kang Myung Joo; Cho Ha Ra; Lee Dong Hoon; Yeom Dong Woo; Choi Young Wook; Choi Yong Seok

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A Method to Monitor Dutasteride in Rat Plasma Using Liquid-Liquid Extraction and Multiple Reaction Monitoring: Comparisons and Validation

机译：液-液萃取和多反应监测监测大鼠血浆中度他雄胺的方法：比较和验证

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Three different dutasteride extraction methods were compared and a method based on liquid-liquid extraction (LLE) using methyl tert-butyl ether and methylene chloride was proved to be more effective than others for the extraction of dutasteride and finasteride, the internal standard (IS), from rat plasma. Additionally, a method composed of the LLE extraction, liquid chromatography, and multiple reaction monitoring (MRM) to target dutasteride and IS was validated by assessing specificity, linearity (.

机译：比较了三种不同的度他雄胺的提取方法，并证明了使用甲基叔丁基醚和二氯甲烷进行液-液萃取（LLE）的方法在提取度他雄胺和非那雄胺（内标）方面比其他方法更有效。，来自大鼠血浆。此外，通过评估特异性，线性（）验证了一种方法，该方法由LLE提取，液相色谱法和针对Dutasteride和IS的多反应监测（MRM）组成。

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《Mass Spectrometry Letters》 |2014年第3期|共5页
作者
Kang Myung Joo; Cho Ha Ra; Lee Dong Hoon; Yeom Dong Woo; Choi Young Wook; Choi Yong Seok;
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A Method to Monitor Dutasteride in Rat Plasma Using Liquid-Liquid Extraction and Multiple Reaction Monitoring: Comparisons and Validation

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