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首页> 外文期刊>Medical Journal of Shree Birendra Hospital >Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.
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Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.

机译：伊曲康唑与特比萘芬治疗替硝草的疗效。

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Introduction: Tenia Cruris is the commonest dermatophyte infection which is common in men and aggravated by warm humid condition Teniarubrum is the main species for the disease1, 2. Itraconazole and Terbinafine are the better newer drugs for the therapeutic option due to their efficacy, convenient and less side effect. Itraconazole is a wider spectrum Thiazole group of fungistatic drugs which inhibit sterol 14 ? demethylase impairing biosynthesis of fungal ergosterol. Similarly Terbinafine is broad specturmallylamine group of fungicidal activity which inhibits squalene 2, 3 epoxidase enzyme thus inhibit fungal biosynsthesis of ergosterol3-5. These two drugs have been needed conventionally as a pulse and continuous therapy. The main aim of this study is to compare the efficacy of both drugs and to recommend the eff ective treatment in case of Teniacruris. Methods: In this randomized comparative study, the efficacy and safety of oral itraconazole (n=35) and terbinafine (n=35), each given for 2weeks, was compared in patients with tineacruris within the period of 1 year study. Results: The final evaluation at week 4 showed a cure rate of 91.4% for itraconazole and 82.9% for terbinafine. No definite adverse effect was noted. Conclusions: Itraconazolehas high cure rate and less failure rate without side effects in comparision to Terbinafine. Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/24-26 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7763
机译：简介：Tenia Cruris是最常见的皮肤癣菌感染，在男性中普遍存在，并因温暖潮湿而加重。Teniarubrum是该病的主要病种1、2。伊曲康唑和特比萘芬因其疗效，便利性和易用性成为更好的新型治疗药物。副作用少。伊曲康唑是广谱的噻唑类抑真菌药物，可抑制甾醇14？脱甲基酶损害真菌麦角固醇的生物合成。类似地，特比萘芬是具有杀真菌活性的广谱烯丙胺基团，其抑制角鲨烯2、3环氧化酶，从而抑制麦角固醇3-5的真菌生物合成。常规上，这两种药物需要作为脉冲疗法和连续疗法。这项研究的主要目的是比较两种药物的功效，并推荐对Teniacruris的有效治疗方法。方法：在这项随机对照研究中，比较了在为期1年的研究中对患有尖锐湿疣的患者口服伊曲康唑（n = 35）和特比萘芬（n = 35）2周的疗效和安全性。结果：在第4周的最终评估结果显示，伊曲康唑的治愈率为91.4％，特比萘芬的治愈率为82.9％。没有观察到明确的不良反应。结论：与特比萘芬相比，伊曲康唑治愈率高，失败率低，无副作用。 Shree Birendra医院医学杂志; 2012年1月6日/vol.11/Issue1/24-26 DOI：http：//dx.doi.org/10.3126/mjsbh.v11i1.7763

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