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首页> 外文期刊>Medical Journal of Shree Birendra Hospital >Ceftriaxone, ofloxacin or both in the treatment of enteric fever
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Ceftriaxone, ofloxacin or both in the treatment of enteric fever

机译：头孢曲松，氧氟沙星或两者同时治疗肠热

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Introduction: Enteric fever is a common diagnosis in febrile patients admitting to the hospital of Nepal. The treatment of enteric fever, though looks straightforward, in recent times has been complicated by emerging resistance to various antibiotics including fluoroquinolones and cephalosporins.Methods: This was a randomized clinical study done at Shree Birendra Hospital from January 2011 to December 2011. Patients with with high grade fever, headache, relative bradycardia, abdominal pain, diarrhoea or constipation with normal to low leukocyte count were clinically diagnosed as Enteric fever and were randomized to either ofloxacin or ceftriaxone group, both well accepted first line treatment for enteric fever and observed for at least five days before the addition of the second drug that is ceftriaxone in ofloxacin group and ofloxacin in ceftriaxonegroup and the response to the drug was noted in terms of defervescence of fever.Results: Total 50 patients were enrolled, 25 in each treatment group. After five days, six patients in Ceftriaxone group needed addition of Ofloxacin and two patients in Ofloxacin group needed Ceftriaxone. The average fever defervescence time in Ceftriaxone group was 3.88 days and in Ofloxacin group was 3.04 days. All patients were afebrile by 9 days of antibiotics.Conclusions: Fever defervescence time with Ofloxacin was lesser than ceftriaxone group and need of supplementary antibiotic is lesser in ofloxacine group. So, ofloxacin can be recommended as 1st line drug for enteric fever.Medical Journal of Shree Birendra Hospital; January-June 2013/vol.12/Issue1/37-40DOI: http://dx.doi.org/10.3126/mjsbh.v12i1.9092
机译：简介：肠热是入尼泊尔医院的高热患者的常见诊断。肠热的治疗虽然看似简单，但近来由于对各种抗生素（包括氟喹诺酮类和头孢菌素类）产生的耐药性而变得复杂。方法：这是于2011年1月至2011年12月在Shree Birendra医院进行的一项随机临床研究。高烧，头痛，相对心动过缓，腹痛，腹泻或便秘或白细胞计数正常的便秘被诊断为肠热，并随机分配给氧氟沙星或头孢曲松组，均接受肠热一线治疗并观察到至少在服用氧氟沙星组的第二种药物头孢曲松和头孢曲松组的氧氟沙星之前至少五天，并以退热的方式记录了对药物的反应。结果：共入组50例患者，每个治疗组25例。五天后，头孢曲松组的6例患者需要补充氧氟沙星，而氧氟沙星组的2例患者需要注射头孢曲松。头孢曲松组平均退热时间为3.88天，氧氟沙星组平均退热时间为3.04天。结论：氧氟沙星的退热时间少于头孢曲松组，氧氟沙星组的补充抗生素需求减少。因此，氧氟沙星可以被推荐为肠热的一线药物。 2013年1月至6月/vol.12/Issue1/37-40DOI：http://dx.doi.org/10.3126/mjsbh.v12i1.9092

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