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首页> 外文期刊>Medical science monitor : >Soluble interleukin 2 receptor (sIL-2R) and interleukin 8 (IL-8) serum concentrations in patients with psoriasis relationship to extent and duration of disease
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Soluble interleukin 2 receptor (sIL-2R) and interleukin 8 (IL-8) serum concentrations in patients with psoriasis relationship to extent and duration of disease

机译：银屑病患者可溶性白介素2受体（sIL-2R）和白介素8（IL-8）血清浓度与疾病程度和病程有关

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摘要

Psoriasis is an inflammatory disorder characterized by hyperproliferation of keratinocytes, in which the production of various cytokines is substentially altered. The aim of the study was to compare soluble interleukin 2 receptor (sIL-2R) and interleukin 8 (IL-8) concentrations in psoriatic patients with a control group, as well as to evaluate the level of these markers in relation to the psoriasis severity and activity index (PASI) and the duration of the disease. Concentrations of sIL-2R were determined in 39 patients, IL-8 in 10 patients and in 11 persons of the control group. Statistically significant differences were found between values for psoriatic patients and for the control group. The results of sIL-2R determinations reveal their close with the extent of the disease as evaluated by PASI score. No statistical relationship between the concentrations of the cytokine markers and the duration of the disease was observed.
机译：银屑病是一种以角质形成细胞过度增殖为特征的炎症性疾病，其中各种细胞因子的产生都发生了实质性的改变。该研究的目的是比较银屑病与对照组中可溶性白细胞介素2受体（sIL-2R）和白细胞介素8（IL-8）的浓度，并评估与银屑病严重程度相关的这些标志物的水平以及活动指数（PASI）和疾病持续时间。在对照组的39例患者中测定了sIL-2R的浓度，在10例患者中测定了IL-8，在11人中测定了IL-8。在银屑病患者和对照组之间发现统计学上的显着差异。 sIL-2R测定的结果表明，与PASI评分所评估的疾病程度相近。在细胞因子标志物的浓度与疾病持续时间之间未发现统计学关系。

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