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首页> 外文期刊>Medical science monitor : >Effects of interaction between cadmium and selenium on hepatic metabolism in mice. Part I: The study on DNA, RNA and protein synthesis activities in mouse hepatocytes
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Effects of interaction between cadmium and selenium on hepatic metabolism in mice. Part I: The study on DNA, RNA and protein synthesis activities in mouse hepatocytes

机译：镉和硒之间的相互作用对小鼠肝脏代谢的影响。第一部分：小鼠肝细胞中DNA，RNA和蛋白质合成活性的研究

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Industrial wastes include heavy metals such as cadmium (Cd). Studies on Cd revealed that it is almost exlusively toxic in its effects on metabolism. Selenium (Se) a presequisite for proper functioning of the organism. Several data indicate that Se may be a potential suppressor of noxious Cd effects.We investigated the effects of dietary Cd intoxication on the incorparation of precursors of DNA, RNA and protein synthesis in mouse hepatocytes and compared them with the results of Cd-Se interaction.The results demonstrate that compared to controls 3H-thymidine uptake in the hepatocyte was decreased by 17% in the Cd-diet mice and increased by 13% and 2% in the Sediet and the Cd-Se-diet mice respectively. The 3H-uridine uptake was enhanced by 84% in the Cd-diet group (pM0.05) and by 78% (p0.05) in the Cd-Se-diet group, but it was decreased by 10% in the Se-group. The 3H-alanine uptake by proteins was increased by 82% (p0.05) in the Cd-group and was the highest in the Se-group (126%) (p0.05). In the Cd-Se-diet group the uptake was decreased by 24%. We concluded that in mouse hepatocytes Cd intoxication distorted the incorporation of precursors of nucleic acids and protein synthesis. However, Cd-Se intoxication showed that selenium suppressed the toxic effects of cadmium.
机译：工业废物包括重金属，例如镉（Cd）。对镉的研究表明，它对代谢的作用几乎是排毒的。硒（Se）是机体正常运转的先决条件。几项数据表明，硒可能是潜在的Cd有害抑制剂。我们研究了饮食中Cd中毒对小鼠肝细胞DNA，RNA和蛋白质合成前体整合的影响，并将其与Cd-Se相互作用的结果进行了比较。结果表明，与对照组相比，Cd饮食小鼠中肝细胞对3H胸苷的摄取降低了17％，而Sediet和Cd-Se-饮食小鼠中的3H-胸苷摄取分别增加了13％和2％。 Cd-饮食组的3H-尿苷摄取增加了84％（pM0.05），而Cd-Se-饮食组的3H-尿苷摄取增加了78％（p <0.05），而Se-饮食组降低了10％。组。 Cd组蛋白质的3H丙氨酸摄取增加了82％（p <0.05），而Se组的最高3H丙氨酸摄取（126％）（p <0.05）。在镉硒饮食组中，摄取减少了24％。我们得出的结论是，在小鼠肝细胞中，镉中毒会扭曲核酸和蛋白质合成前体的掺入。但是，Cd-Se中毒表明硒抑制了镉的毒性作用。

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