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首页> 外文期刊>Medical Gas Research >A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level
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A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

机译：急性脑缺血患者吸入分子氢（H2）进行生理学参数安全检查和血液H2水平测量的基础研究

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Background In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenerative striatonigral tissue and also in many other situations. However, since cerebral ischemia patients are in old age group, the safety information needs to be confirmed. For the feasibility of H2 treatment in these patients, delivery of H2 by inhalation method needs to be checked for consistency. Methods Hydrogen concentration (HC) in the arterial and venous blood was measured by gas chromatography on 3 patients, before, during and after 4% (case 1) and 3% (case2,3) H2 gas inhalation with simultaneous monitoring of physiological parameters. For a consistency study, HC in the venous blood of 10 patients were obtained on multiple occasions at the end of 30-min H2 inhalation treatment. Results The HC gradually reached a plateau level in 20 min after H2 inhalation in the blood, which was equivalent to the level reported by animal experiments. The HC rapidly decreased to 10% of the plateau level in about 6 min and 18 min in arterial and venous blood, respectively after H2 inhalation was discontinued. Physiological parameters on these 3 patients were essentially unchanged by use of hydrogen. The consistency study of 10 patients showed the HC at the end of 30-min inhalation treatment was quite variable but the inconsistency improved with more attention and encouragement. Conclusion H2 inhalation of at least 3% concentration for 30 min delivered enough HC, equivalent to the animal experiment levels, in the blood without compromising the safety. However, the consistency of H2 delivery by inhalation needs to be improved.
机译：背景技术在动物实验中，分子氢（H 2 ）的使用被认为是非常安全和有效的，在多种病理状况（例如脑，心脏，肾脏和移植物的缺血再灌注损伤）中显示出益处组织，脑和脊髓的外伤和手术损伤，肠和肺的炎症，变性的纹状体和黑质组织以及许多其他情况。但是，由于脑缺血患者属于老年组，因此需要确认安全信息。为了在这些患者中治疗H 2 的可行性，需要检查通过吸入法递送H 2 的一致性。方法采用气相色谱法分别对3例H 2 气中4％（病例1）和3％（例2,3）H 2 气中的患者进行动脉和静脉血中氢气浓度的测定。吸入同时监测生理参数。为了进行一致性研究，在H 2 吸入治疗30分钟结束后，多次获得了10名患者静脉血中的HC。结果吸入H 2 后20min内HC逐渐达到平稳水平，相当于动物实验报道的水平。停止吸入H 2 后，分别在大约6分钟和18分钟内，HC迅速降低至高原水平的10％。通过使用氢气，这三名患者的生理参数基本没有变化。对10位患者的一致性研究表明，吸入治疗30分钟结束时的HC差异很大，但随着更多关注和鼓励，这种不一致得到改善。结论吸入至少3％浓度的H 2 30分钟可在血液中提供足够的HC，相当于动物实验水平，而不会影响安全性。然而，通过吸入递送H 2 的一致性需要提高。

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