...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research bulletin >Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway
【24h】

Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

机译：通过PI3K / Akt / Nrf2途径诱导HSP70诱导H2S吸入的预处理可预防脑缺血/再灌注损伤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is of great importance to protect the brain against cerebral ischemia and reperfusion (I/R) injury, which leads to excitotoxicity, redox imbalance, inflammation and apoptosis; however, there is currently no effective treatment. The present study aimed to investigate the effect of H2S preconditioning on cerebral I/R injury and its underlying mechanism. The results demonstrated that H2S preconditioning significantly prevented the development of neurological function abnormality, inflammation and oxidatiire injury in mice as well as cognitive impairment caused by cerebral I/R. H2S preconditioning also suppressed the apoptosis caused by cerebral I/R. Moreover, the protective effect of H2S preconditioning was found to involve heat shock protein 70 (HSP70), in which the PI3K/Akt/Nrf2 pathway was involved. The data showed that H2S preconditioning could protect mice against cerebral I/R injury by the induction of HSP70 and the PI3K/Akt/Nrf2 pathway. (C) 2016 Elsevier Inc. All rights reserved.
机译：保护大脑免受脑缺血和再灌注（I / R）损伤的损害，这会导致兴奋性毒性，氧化还原失衡，炎症和细胞凋亡，这一点非常重要。但是，目前尚无有效的治疗方法。本研究旨在探讨H2S预处理对脑I / R损伤的影响及其潜在机制。结果表明，H2S预处理可显着预防小鼠神经功能异常，炎症和氧化损伤以及脑I / R引起的认知障碍的发展。 H2S预处理还抑制了由脑I / R引起的细胞凋亡。此外，发现H2S预处理的保护作用涉及热激蛋白70（HSP70），其中涉及PI3K / Akt / Nrf2途径。数据表明，H2S预处理可以通过诱导HSP70和PI3K / Akt / Nrf2途径来保护小鼠免受脑I / R损伤。 （C）2016 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号