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首页> 外文期刊>Medicine. >The effect of acupuncture on the expression of inflammatory factors TNF-α, IL-6,IL-1 and CRP in cerebral infarction: A protocol of systematic review and meta-analysis
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The effect of acupuncture on the expression of inflammatory factors TNF-α, IL-6,IL-1 and CRP in cerebral infarction: A protocol of systematic review and meta-analysis

机译：针刺对脑梗死炎性因子TNF-α，IL-6，IL-1和CRP表达的影响：系统评价和荟萃分析的方案

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Background: The mechanisms of acupuncture on the treatment of cerebral infarction remain unclear, the aim of the present study was to provides a protocol of systematic review and meta-analysis , with which we will collect clinical evidence to verify whether acupuncture will have an effect on reducing the levels of tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-1 (IL-1), and interleukin (IL-6) after cerebral infarction based on evidence-based studies. Methods: Included studies will be retrieved according to inclusion and exclusion criteria from 5 English databases (the MEDLINE via PubMed, the Cochrane Library, Embase, the Web of Science, and Ovid database), and 4 Chinese databases (China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), Wan-fang Database, China National Knowledge Infrastructure (CNKI)) from October 1990 to October 2017. The inflammatory factor levels of TNF-α and IL-1,IL-6,CRP will be marked as major outcomes. We will use RevMan V.5.3 software to calculate the data synthesis and will conduct meta-analysis based on the collected data. Results: The inflammatory factor levels of TNF-α and IL-1,IL-6,CRP, mortality and adverse effects will be measured and comprehensively assessed to evaluate the adjunctive effect of XBP on CHF from this systematic review and meta-analysis with current clinical evidence. Conclusion: The systematic review and meta-analysis will assess the effect of acupuncture on the expression of inflammatory factors TNF-α, IL-6, IL-1 and CRP in cerebral infarction with up-to-date clinical evidence. PROSPERO registration number: PROSPERO CRD42017078583.
机译：背景：针灸治疗脑梗死的机制尚不清楚，本研究的目的是提供系统的综述和荟萃分析的方案，我们将收集临床证据以验证针灸是否会对脑梗塞产生影响根据循证研究，可降低脑梗死后肿瘤坏死因子α（TNF-α），C反应蛋白（CRP），白介素1（IL-1）和白介素（IL-6）的水平。方法：根据纳入和排除标准，从5个英文数据库（通过PubMed的MEDLINE，Cochrane图书馆，Embase，Web of Science和Ovid数据库）和4个中文数据库（《中国科学技术期刊》数据库）中检索纳入的研究（VIP），中国生物医学文献数据库（CBM），万方数据库，中国国家知识基础设施（CNKI）从1990年10月至2017年10月。TNF-α和IL-1，IL-6，CRP的炎症因子水平将被标记为主要结果。我们将使用RevMan V.5.3软件来计算数据综合，并将基于收集的数据进行荟萃分析。结果：根据目前的系统评价和荟萃分析，将测量并综合评估炎症因子TNF-α，IL-1，IL-6，CRP，死亡率和不良反应，以评估XBP对CHF的辅助作用。临床证据。结论：系统评价和荟萃分析将评估针刺对脑梗死炎性因子TNF-α，IL-6，IL-1和CRP表达的影响，并提供最新的临床证据。 PROSPERO注册号：PROSPERO CRD42017078583。

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