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首页> 外文期刊>Modern Pathology >Parvalbumin Is Constantly Expressed in Chromophobe Renal Carcinoma
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Parvalbumin Is Constantly Expressed in Chromophobe Renal Carcinoma

机译：小儿白蛋白在发色性肾癌中不断表达

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Chromophobe renal carcinoma is composed of neoplastic cell showing several features similar to those found in the intercalated cells of the collecting ducts. Because the distal nephron expresses calcium-binding proteins playing a role in calcium homeostasis, we reasoned that these proteins could be expressed by chromophobe carcinoma and therefore represent a diagnostic marker. We studied the immunohistochemical expression of different calcium-binding proteins (parvalbumin, calbindin-D28K, and calretinin) in 140 renal tumors, including 75 conventional (clear cell) carcinomas, 32 chromophobe carcinomas, 17 papillary renal cell carcinomas, and 16 oncocytomas. Parvalbumin was strongly positive in all primary chromophobe carcinomas and in one pancreatic metastasis; it was positive in 11 of 16 oncocytomas and absent in conventional (clear cell) and papillary renal cell carcinomas, either primary or metastatic. Calbindin-D28K and calretinin were negative in all tumors, with the exception of two chromophobe carcinomas, four oncocytomas, and two papillary renal cell carcinomas showing inconspicuous calretinin expression. Our data demonstrate that parvalbumin may be a suitable marker for distinguishing primary and metastatic chromophobe carcinoma from conventional (clear cell) and papillary renal cell carcinoma. Moreover, they suggest a relationship between chromophobe renal carcinoma and renal oncocytoma and indicate that chromophobe carcinoma exhibits differentiation toward the collecting-duct phenotype.
机译：嗜铬肾癌由赘生性细胞组成，表现出与收集管插入细胞中发现的特征相似的若干特征。因为远端肾单位表达在钙稳态中起作用的钙结合蛋白，所以我们认为这些蛋白可以由发色团癌表达，因此代表诊断标记。我们研究了140种肾脏肿瘤中不同钙结合蛋白（parvalbumin，calbindin-D28K和calretinin）的免疫组织化学表达，包括75例常规（透明细胞）癌，32例发色细胞癌，17例乳头状肾细胞癌和16例细胞瘤。小白蛋白在所有原发性色母癌和一种胰腺转移中均呈强阳性。它在16个肿瘤细胞瘤中有11个呈阳性，而在传统（透明细胞）和乳头状肾细胞癌（无论是原发性还是转移性）中均不存在。钙结合蛋白-D28K和钙网蛋白在所有肿瘤中均为阴性，除了两个色盲癌，四个肿瘤细胞瘤和两个乳头状肾细胞癌，其钙调蛋白表达不明显。我们的数据表明，小白蛋白可能是区分原发性和转移性发色细胞癌与常规（透明细胞）和乳头状肾细胞癌的合适标志物。此外，他们暗示了发色肾癌与肾上皮细胞瘤之间的关系，并表明发色癌表现出向收集通道表型的分化。

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