Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications

Nancy L Harris

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Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications

机译：大型B细胞淋巴瘤和霍奇金淋巴瘤之间的灰色阴影：鉴别诊断和生物学意义

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Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular sclerosis CHL and primary mediastinal large B-cell lymphoma; CHL rich in lymphocytes and NLPHL; and NLPHL and T-cell/histiocyte-rich LBCL. This review covers the defining features of each of these diseases, the borderlines between them, and strategies for differential diagnosis.

机译：霍奇金淋巴瘤（HLs）是大B细胞的肿瘤。公认两种类型：结节性淋巴细胞为主的HL（NLPHL）和经典HL（CHL）。在这两种类型中，非HL型大B细胞淋巴瘤（LBCL）可能在形态上和生物学上都有重叠。这些包括结节性硬化症CHL和原发性纵隔大B细胞淋巴瘤; CHL富含淋巴细胞和NLPHL; NLPHL和富含T细胞/组织细胞的LBCL。这篇综述涵盖了每种疾病的定义特征，它们之间的界限以及鉴别诊断的策略。

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《Modern Pathology》 |2013年第s1期|共14页
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Nancy L Harris;
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中图分类病理学;
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1. Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. [J] . Calvo KR, Traverse Glehen A, Pittaluga S, Advances in anatomic pathology . 2004,第5期

机译：分子谱分析提供了原发性纵隔大B细胞淋巴瘤作为与经典霍奇金淋巴瘤相关的独特实体的证据：对纵隔灰色区淋巴瘤作为B细胞淋巴瘤的一种中间形式的意义。
2. A malignant lymphoma with histological features and immunophenotypic profile intermediate between EBV-positive diffuse large B-cell lymphoma and EBV-positive classical Hodgkin lymphoma in a 67-year-old female: A " gray zone" lymphoma associated with Epstein-Barr virus in the elderly [J] . WangE., PapavassiliouP., SebastianS. Pathology Research and Practice . 2012,第6期

机译：一名67岁女性在EBV阳性弥漫性大B细胞淋巴瘤和EBV阳性经典霍奇金淋巴瘤之间具有组织学特征和免疫表型特征的恶性淋巴瘤：一种与爱泼斯坦-巴尔病毒相关的“灰色区”淋巴瘤老年
3. Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas. [J] . Loddenkemper C, Anagnostopoulos I, Hummel M, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2004,第1期

机译：在反应性B细胞，B细胞非霍奇金淋巴瘤和霍奇金淋巴瘤中，E增强子活性和BOB.1 / OBF.1，Oct2，PU.1和免疫球蛋白的表达差异。
4. Development of Single Domain Antibodies for Diagnosis and Treatment of Naturally Occurring Canine Lymphoma: An Animal Model for Human Non-Hodgkin Lymphoma [C] . Joana Dias, Solange Gil, Belmira Carrapico, PEGS . 2015

机译：天然犬淋巴瘤诊断和治疗单结构域抗体的发展：人非霍奇金淋巴瘤的动物模型
5. Epigenetic regulation of B-cell transcription factors during germinal center B-cell maturation and their silencing in Hodgkin lymphoma. [D] . Ramachandrareddy, Himabindu. 2012

机译：霍奇金淋巴瘤生发中心B细胞成熟过程中B细胞转录因子的表观遗传调控及其沉默。
6. Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin’s lymphoma and primary mediastinal large B-cell lymphoma [O] . Franziska C. Eberle, Jaime Rodriguez-Canales, Lai Wei, 2011

机译：纵隔灰色区淋巴瘤的甲基化分布显示出独特的特征与经典霍奇金淋巴瘤和原发性纵隔大B细胞淋巴瘤共享
7. Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma [O] . Stefania Pittaluga, Alina Nicolae, George W. Wright, 2020

机译：纵隔灰色区淋巴瘤的基因表达分析及其与原发性纵隔B细胞淋巴瘤和古典霍奇金淋巴瘤的关系

Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications

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