...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Modern Pathology >Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma
【24h】

Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma

机译：B细胞转录因子在原发性皮肤B细胞淋巴瘤中的表达

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with expression patterns during normal B-cell development. The following transcription factors were investigated: Pax-5, PU.1, Oct2, BOB.1, Bcl-6, Mum1/IRF4, Blimp-1 and FOXP1. Primary cutaneous large B-cell lymphomas, leg type showed aberrant coexpression of Bcl-6 and Mum1/IRF4 and in addition strong expression of FOXP1. Expression of FOXP1 and Mum1/IRF4 strongly suggests an activated B-cell type of origin. In contrast, primary cutaneous follicle center lymphomas showed expression of Bcl-6, Pax-5, PU.1, Oct2 and BOB.1, but not of Mum1/IRF4, Blimp-1 and FOXP1. Primary cutaneous marginal zone B-cell lymphoma showed expression of Pax-5, PU.1, Oct2 and BOB.1, but not Bcl-6 by the neoplastic B-cells, and Mum1/IRF4 and Blimp-1 by the neoplastic plasma cells. In conclusion, in primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell lymphoma expression patterns were observed similar to their supposed benign counterparts, germinal center B-cells and postgerminal center B-cells, respectively, which might reflect their indolent clinical behaviour and excellent prognosis. In contrast, the activated B-cell expression pattern in the group of primary cutaneous large B-cell lymphoma, leg type may contribute to its poor prognosis and Mum1/IRF4 and FOXP1 may serve as additional diagnostic markers for this type of primary cutaneous B-cell lymphoma.
机译：在一大批原发性皮肤B细胞淋巴瘤中研究了参与B细胞发育不同阶段的8种转录因子的表达模式，并与正常B细胞​​发育过程中的表达模式进行了比较。研究了以下转录因子：Pax-5，PU.1，Oct2，BOB.1，Bcl-6，Mum1 / IRF4，Blimp-1和FOXP1。腿部类型的原发性皮肤大B细胞淋巴瘤显示Bcl-6和Mum1 / IRF4异常共表达，此外还强烈表达FOXP1。 FOXP1和Mum1 / IRF4的表达强烈暗示了激活的B细胞类型的起源。相比之下，原发性皮肤滤泡中心淋巴瘤显示Bcl-6，Pax-5，PU.1，Oct2和BOB.1的表达，但未检测到Mum1 / IRF4，Blimp-1和FOXP1的表达。原发性皮肤边缘区B细胞淋巴瘤在肿瘤B细胞中表达Pax-5，PU.1，Oct2和BOB.1，但在Bcl-6中不表达，而在肿瘤浆细胞中显示Mum1 / IRF4和Blimp-1。 。总之，在原发性皮肤滤泡中心淋巴瘤和原发性皮肤边缘区B细胞淋巴瘤的表达模式分别类似于其假定的良性对应物，生发中心B细胞和生殖器中心B细胞，这可能反映了它们的惰性行为和良好的预后相比之下，原发性皮肤大B细胞淋巴瘤，腿型组中活化的B细胞表达模式可能有助于其不良预后，而Mum1 / IRF4和FOXP1可以作为此类原发性皮肤B-淋巴瘤的其他诊断标志物细胞淋巴瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号