Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

Timur R Samatov; Alexander G Tonevitsky; Udo Schumacher

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Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

机译：上皮-间充质转化：专注于转移级联，选择性剪接，非编码RNA和调节化合物

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Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.

机译：上皮-间质转化（EMT）是恶性进展期间胚胎发育和转移形成的关键过程。这篇综述着重于EMT期间的转录调控，非编码RNA，选择性剪接事件和细胞粘附分子调控。此外，我们总结了有关能够调节EMT用于癌症治疗的潜在小分子药物的知识。

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《Molecular Cancer》 |2013年第1期|共页
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Timur R Samatov; Alexander G Tonevitsky; Udo Schumacher;
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1. HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition [J] . Sakuma Keiichiro, Sasaki Eiichi, Kimura Kenya, Gut: Journal of the British Society of Gastroenterology . 2018,第6期

机译：HNRNPLL是一种新鉴定的结肠直肠癌转移抑制剂，在上皮 - 间充质过渡期间调节CD44的替代剪接
2. HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition [J] . Sakuma Keiichiro, Sasaki Eiichi, Kimura Kenya, Fortschritte der Physik . 2018,第6期

机译：HNRNPLL是一种新鉴定的结肠直肠癌转移抑制剂，在上皮 - 间充质过渡期间调节CD44的替代剪接
3. Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition [J] . Baranwal Somesh Frontiers in Cell and Developmental Biology . 2017,第1期

机译：评论：HNRNPLL是一种新发现的结直肠癌转移抑制因子，可在上皮-间质转化过程中调节CD44的可变剪接
4. Structural genomics analysis of alternative splicing and its application in modeling structures of alternatively spliced variants [C] . Peng Wang, Bo Yan, Juntao Guo, . 2005

机译：替代剪接的结构基因组学分析及其在替代剪接变体结构建模中的应用
5. Genetic novelties generated by non-coding RNAs and alternative splicing in Drosophila. [D] . Chen, Ying. 2008

机译：通过非编码RNA和果蝇的选择性剪接产生的遗传新奇。
6. Epithelial-mesenchymal transition: focus on metastatic cascade alternative splicing non-coding RNAs and modulating compounds [O] . Timur R Samatov, Alexander G Tonevitsky, Udo Schumacher 2013

机译：上皮-间充质转变：专注于转移级联选择性剪接非编码RNA和调节化合物
7. Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds [O] . Timur R Samatov, Alexander G Tonevitsky, Udo Schumacher 2013

机译：上皮-间充质转变：专注于转移级联，选择性剪接，非编码RNA和调节化合物

Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

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