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首页> 外文期刊>Nepal Journal of Epidemiology >Effect of Age, Sex and Pregnancy on Levels of Urinary Inhibitors of mineralization in Human Beings
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Effect of Age, Sex and Pregnancy on Levels of Urinary Inhibitors of mineralization in Human Beings

机译：年龄，性别和怀孕对人矿化尿泌素水平的影响

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Background: Based upon the differences observed in the level of urinary inhibitors between adult normal subjects of both sexes and kidney stone patients of identical sex, it has been postulated that urinary inhibitors play an important role in the control of pathological mineralization. Review of literature revealed that corresponding studies on the level of urinary inhibitors in children of both sexes and during various stages of pregnancy are not available. These studies, so important to investigate the role of inhibitors in physiological mineralization, formed the objective of the present study. Materials and Methods: Homogenous system of?In vitro?mineralization was employed to study not only the extend of mineralization and the effect of various urine samples obtained from normal subjects of both sexes and pregnant females at various trimesters of pregnancy on extend of mineralization but also to quantify the level of the inhibitors. Results: Using?in vitro?system of mineralization (precipitation of Ca2+?or HPO4?2-?ions as mineral phase), it has been shown that in contrast to the adult human beings, in children of less than 13 years of age no significant differences exists in the level of the urinary inhibitors between males and females children provided experimental support to the epidemiological studies on the occurrence of the renal calculosis problem in both sexes of children and adult human beings. The findings that the level of the urinary inhibitors of mineralization in both sexes of children is as high as present in adult females and that a highly significant decrease in their levels occurs during the 3rd trimester of pregnancy strongly suggests that hormones may be playing an important role in regulating their levels. Conclusion: Inhibitors of mineralization excreted in urine of normal healthy subjects of both sexes of Children (20 years), kidney stone patients at these ages, non pregnant and pregnant females (during various trimesters of pregnancy) have been postulated to play an important role in the control of both physiological and pathological mineralization.DOI: http://dx.doi.org/10.3126je.v4i4.11360 Nepal Journal of Epidemiology 2014; 4(4):399-404
机译：背景：基于观察到的男女成年正常受试者和同性肾结石患者之间尿液抑制剂水平的差异，推测尿液抑制剂在控制病理性矿化中起重要作用。文献综述表明，尚无关于男女儿童和妊娠各个阶段尿液抑制剂水平的相应研究。这些研究对研究抑制剂在生理矿化中的作用至关重要，因此构成了本研究的目标。材料与方法：采用体外矿化的均质系统，不仅研究矿化的延长以及在妊娠三个月从正常性别的雌性和怀孕女性获得的各种尿液样本对矿化延长的影响，还研究了量化抑制剂的水平。结果：利用体外矿化系统（Ca 2+或HPO4 2 2-离子的沉淀为矿相），已证明与成年人相比，在13岁以下的儿童中没有男女儿童的尿液抑制剂水平存在显着差异，这为流行病学研究提供了实验依据，以研究男女儿童和成年人中肾结石问题的发生。研究发现，男女儿童的尿液矿化抑制剂水平与成年女性一样高，并且在妊娠的第三个月期间其水平显着降低，这强烈表明激素可能起着重要作用。在调节他们的水平。结论：假定在儿童（20岁），这些年龄的正常健康受试者，这些年龄的肾结石患者，未怀孕和怀孕的女性（在怀孕的各个三个月中）的尿液中排出的矿化抑制剂被认为在尿液中起重要作用。 DOI：http：//dx.doi.org/10.3126je.v4i4.11360尼泊尔流行病学杂志2014; 4（4）：399-404

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