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首页> 外文期刊>Kaohsiung Journal of Medical Sciences >Effect of platelet-rich plasma on reconstruction with nerve autografts
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Effect of platelet-rich plasma on reconstruction with nerve autografts

机译：富血小板血浆对神经自体移植重建的影响

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摘要

Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has been reported to have positive effects on nerve regeneration, as well as on tissue healing. The present study was designed to evaluate the effect of PRP on nerve-grafted defects. Sprague–Dawley rats were divided into four surgery groups ( n = 7 in each). A 1-cm long nerve defect was created in the upper thigh and then reconstructed using a nerve autograft in all groups. The wet muscle weights, electromyographic findings, and histomorphologic changes were evaluated 10 weeks later. As shown by both the electromyographic ( p 0.001) and histomorphologic findings ( p 0.001), PRP had more positive effects on nerve gap reconstruction in Group 3 then Group 4 as compared to the control groups. The present study is novel in that it evaluated the regeneration effect of PRP on a large nerve defect reconstructed with a nerve graft rather than primary repair. The results are encouraging for further experimental studies on the role of PRP in nerve healing.
机译：尽管对周围神经损伤和再生的理解有所进步，并且外科技术也有所进步，但重建手术后仍无法保证成功的预后。据报道，富含血小板的血浆（PRP）对神经再生以及组织愈合有积极作用。本研究旨在评估PRP对神经移植缺损的影响。 Sprague-Dawley大鼠分为四个手术组（每组n = 7）。在大腿上部创建了一个1厘米长的神经缺损，然后在所有组中使用神经自体移植进行了重建。 10周后评估湿肌重量，肌电图表现和组织形态学变化。如肌电图（p <0.001）和组织形态学结果（p <0.001）所示，与对照组相比，PRP对第3组和第4组的神经间隙重建具有更积极的作用。本研究是新颖的，因为它评估了PRP对用神经移植而非一次修复重建的大神经缺损的再生作用。有关PRP在神经愈合中作用的进一步实验研究的结果令人鼓舞。

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