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首页> 外文期刊>Neural regeneration research >Electroacupuncture at Baihui (DU20) acupoint up-regulates mRNA expression of NeuroD molecules in the brains of newborn rats suffering in utero fetal distress
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Electroacupuncture at Baihui (DU20) acupoint up-regulates mRNA expression of NeuroD molecules in the brains of newborn rats suffering in utero fetal distress

机译：百会穴电针上调宫内胎儿窘迫新生大鼠脑内NeuroD分子的mRNA表达

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NeuroD plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain. Thus, we assumed that electroacupuncture at Baihui (DU20) acupoint in newborn rats exposed to in utero fetal distress would influence expression of NeuroD. Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old (Day 3) newborn Sprague-Dawley rats exposed to in utero fetal distress; electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2-10 Hz. Real-time fluorescent quantitative PCR results demonstrated that mRNA expression of NeuroD, a molecule that indicates NeuroD, increased with prolonged time in brains of newborn rats, and peaked on Day 22. The level of mRNA expression was similar between Day 16 and Day 35. These findings suggest that electro acupuncture at Baihui acupoint could effectively increase mRNA expression of molecules involved in NeuroD in the brains of newborn rats exposed to in utero fetal distress.
机译：NeuroD对神经干细胞分化为大脑中成熟的神经元起着关键的调节作用。因此，我们假设在子宫内胎儿窘迫中暴露的新生大鼠百会穴（DU20）电针会影响NeuroD的表达。对3天大（第3天）新生宫内胎儿窘迫的Sprague-Dawley大鼠进行百会电针治疗20分钟。电针参数由稀疏波和密集波组成，频率为2-10 Hz。实时荧光定量PCR结果表明，新生鼠的大脑中NeuroD的分子mRNA表达随时间的延长而增加，并在第22天达到峰值。第16天和第35天的mRNA表达水平相似。这些发现表明，百会穴电针可以有效地增加宫内胎儿窘迫新生大鼠大脑中NeuroD分子的mRNA表达。

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