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首页> 外文期刊>Neuropsychopharmacology >Effect of Cannabinoid CB1 Receptor Antagonist SR141714A and CB1 Receptor Knockout on Cue-Induced Reinstatement of Ensure|[reg]| and Corn-Oil Seeking in Mice
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Effect of Cannabinoid CB1 Receptor Antagonist SR141714A and CB1 Receptor Knockout on Cue-Induced Reinstatement of Ensure|[reg]| and Corn-Oil Seeking in Mice

机译：大麻素CB1受体拮抗剂SR141714A和CB1受体敲除对Cue诱导的sure恢复的作用| [reg] |和寻求老鼠的玉米油

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The cannabinoid CB1 receptor antagonist SR141716A decreases cue-induced reinstatement of sucrose and drug seeking in rats. Reinstatement behavior is not well characterized in C57Bl/6 mice, including CB1 receptor knockout mice generated on a C57Bl/6 background. In the present study, male C57Bl/6, CB1 knockout (CB1 KO), and wild-type littermate (WT) mice were trained to respond for the sweet reinforcer Ensure? or corn oil. Responding was maintained on a fixed ratio 1 (FR1) schedule of reinforcement for 10 days, and then extinguished by the removal of the reinforcer and associated cues. Subsequently, the effect of either pretreatment with SR141716A or CB1 receptor knockout on cue-induced reinstatement of Ensure? or corn-oil seeking was assessed. Both 1.0 and 3.0mg/kg SR141716A decreased reinstatement of Ensure? seeking in C57Bl/6 mice. A tenfold higher dose of SR141716A (10.0mg/kg) was required to attenuate reinstatement behavior in C57Bl/6 mice responding for corn oil, suggesting that CB1 receptors may be selectively involved in the neurobiology underlying reinstatement of responding for some food reinforcers but not others. Whereas CB1 receptor antagonism selectively attenuated reinstatement of responding for Ensure?, genetic deletion of the CB1 receptor produced only a trend in decreasing reinstatement of Ensure? seeking, and did not attenuate reinstatement of corn-oil seeking. Baseline differences in levels of operant responding were also observed in WT vs CB1 KO mice maintained by Ensure? and corn oil. This and other possible reasons for the observed discrepancy between pharmacological blockade vs genetic invalidation of the CB1 receptor on reinstatement of Ensure? seeking are discussed.
机译：大麻素CB1受体拮抗剂SR141716A降低了提示诱导的大鼠蔗糖恢复和药物寻找。在C57Bl / 6小鼠中，包括在C57Bl / 6背景上产生的CB1受体基因敲除小鼠中，恢复行为的特征不充分。在本研究中，训练了雄性C57Bl / 6，CB1基因敲除（CB1 KO）和野生型同窝仔（WT）小鼠对甜味增强剂做出反应。或玉米油。响应按固定比例1（FR1）的时间表进行，持续10天，然后通过移除增强器和相关提示将其熄灭。随后，用SR141716A或CB1受体敲除的预处理对提示诱导的sure？恢复的影响。或寻求玉米油。 SR141716A 1.0和3.0mg / kg SR的恢复均降低了？寻找C57Bl / 6小鼠。需要10倍高剂量的SR141716A（10.0mg / kg）来减弱对玉米油有反应的C57Bl / 6小鼠的恢复行为，这表明CB1受体可能选择性地参与了对某些食物增强剂的响应而恢复潜在的神经生物学作用。 。 CB1受体拮抗作用选择性减弱了对Secure？反应的恢复，而CB1受体的基因缺失仅产生了减少sure？恢复的趋势。寻求，并且没有削弱恢复玉米油的寻求。还确保在野生型与CB1 KO小鼠之间通过操作确保水平保持基线差异。和玉米油。这和其他可能的原因有关，在恢复“确保？”后药理学封锁与CB1受体遗传失效之间存在差异。寻找进行了讨论。

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