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首页> 外文期刊>Neuropsychopharmacology >Effect of CYP2D6 Genotypes on the Metabolism of Haloperidol in a Japanese Psychiatric Population
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Effect of CYP2D6 Genotypes on the Metabolism of Haloperidol in a Japanese Psychiatric Population

机译：CYP2D6基因型对氟哌啶醇在日本精神病人群中代谢的影响

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We investigated the effect of CYP2D6 genotypes on plasma levels of haloperidol (HAL) and reduced haloperidol (RHAL) in 88 Japanese schizophrenic inpatients being treated with HAL. Some subjects carrying CYP2D6*5 allele (CYP2D6*1/CYP2D6*5, CYP2D6*5/CYP2D6*10) showed extremely high concentrations of both HAL and RHAL, and the groups with CYP2D6*5 allele seemed to have higher plasma concentrations of HAL (1.140.69ng/ml/mg) and RHAL (1.101.05ng/ml/mg) than the other groups. Among those without CYP2D6*5 allele, there were no significant differences in plasma concentrations of HAL and RHAL between those without CYP2D6*10 allele (HAL=0.680.31ng/ml/mg, RHAL=0.280.37ng/ml/mg), those with one CYP2D6*10 (HAL=0.700.23ng/ml/mg, RHAL=0.310.16ng/ml/mg) and those with two CYP2D6*10 alleles (HAL=0.690.14ng/ml/mg, RHAL=0.400.09ng/ml/mg), although there was a tendency of higher plasma concentration of RHAL in those with two CYP2D6*10 alleles. At a lower daily dosage of HAL (CYP2D6*10 allele(s) showed significantly higher plasma concentrations of RHAL (0.430.23ng/ml/mg, 0.340.16ng/ml/mg) than those without CYP2D6*10 allele (0.180.16ng/ml/mg). The results of this study indicate that CYP2D6*10 allele plays significant but modest role in HAL metabolism in Japanese; nevertheless, we should not lump CYP2D6*10 allele with CYP2D6*5 allele because these two mutated alleles seem to have different impacts in the metabolism of HAL.
机译：我们调查了CYP2D6基因型对氟哌啶醇（HAL）和降低的氟哌啶醇（RHAL）的血浆水平对88名接受HAL治疗的日本精神分裂症患者的影响。一些携带CYP2D6 * 5等位基因的受试者（CYP2D6 * 1 / CYP2D6 * 5，CYP2D6 * 5 / CYP2D6 * 10）均显示HAL和RHAL的浓度都很高，而CYP2D6 * 5等位基因的组似乎具有较高的HAL血浆浓度（1.140.69ng / ml / mg）和RHAL（1.101.05ng / ml / mg）高于其他组。在没有CYP2D6 * 5等位基因的患者中，没有CYP2D6 * 10等位基因的患者（HAL = 0.680.31ng / ml / mg，RHAL = 0.280.37ng / ml / mg）之间的HAL和RHAL血浆浓度无明显差异具有一个CYP2D6 * 10（HAL = 0.700.23ng / ml / mg，RHAL = 0.310.16ng / ml / mg）和具有两个CYP2D6 * 10等位基因（HAL = 0.690.14ng / ml / mg，RHAL = 0.400.09ng） / ml / mg），尽管在有两个CYP2D6 * 10等位基因的人群中，RHAL的血浆浓度有升高的趋势。每日HAL剂量较低时（CYP2D6 * 10等位基因显示）RHAL的血浆浓度（0.430.23ng / ml / mg，0.340.16ng / ml / mg）显着高于无CYP2D6 * 10等位基因（0.180.16ng / ml / mg）。这项研究的结果表明，CYP2D6 * 10等位基因在日本人的HAL代谢中起着重要作用，但作用不大;尽管如此，我们不应将CYP2D6 * 10等位基因与CYP2D6 * 5等位基因混为一谈，因为这两个突变等位基因似乎对HAL的代谢有不同的影响。

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