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首页> 外文期刊>Neuroscience Journal >Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats
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Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats

机译：随年龄变化的大鼠癫痫发作和固有频率动态变化

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The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sleep spindles demonstrated an increase of instantaneous frequency from beginning to the end. At the age of 7 and 9 months, when animals developed matured and longer epileptic discharges (symptomatic stage), their sleep spindles did not display changes of intrinsic frequency. The present data suggest that age-dependent increase of epileptic activity in WAG/Rij rats affects intrinsic dynamics of sleep spindle frequency.
机译：神经系统疾病的风险会随着年龄的增长而增加。在无癫痫的WAG / Rij大鼠模型中，癫痫性尖峰波放电的发生率随着年龄的增长而增加。考虑到癫痫尖峰波放电与生理性睡眠纺锤之间的密切关系，可以认为，随着年龄的增长，癫痫活动可能会影响睡眠纺锤的时频特性。为了检验这一假设，分别在5、7和9个月大的WAG / Rij大鼠中记录了脑电图（EEG）。在额叶脑电通道中检测到尖峰波放电和睡眠纺锤体。使用基于小波的算法自动识别睡眠纺锤。使用EEG信号的连续小波变换确定睡眠纺锤体的瞬时（时间局部）频率，并进一步检查纺锤体内的频率动态。发现在5个月大的大鼠中，癫痫活动尚未完全发展（临床前阶段），并且睡眠纺锤体显示出从开始到结束的瞬时频率增加。在7个月和9个月大时，当动物发育成熟并出现较长的癫痫发作（有症状的阶段）时，它们的睡眠纺锤体就没有内在频率的变化。本数据表明，WAG / Rij大鼠中癫痫活动的年龄依赖性增加会影响睡眠纺锤体频率的内在动力学。

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