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首页> 外文期刊>New Microbes and New Infections >Prevalence of methicillin resistance and macrolide-lincosamide-streptogramin B resistance in Staphylococcus haemolyticus among clinical strains at a tertiary-care hospital in Thailand
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Prevalence of methicillin resistance and macrolide-lincosamide-streptogramin B resistance in Staphylococcus haemolyticus among clinical strains at a tertiary-care hospital in Thailand

机译：泰国三级医院的临床菌株中溶血性葡萄球菌对甲氧西林的耐药性和大环内酯类-林可酰胺-链霉菌素B耐药的发生率

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Staphylococcus spp. is a major cause of nosocomial infection and sepsis. However, increasing drug resistance is becoming a challenge to microbiologists. The purpose of this study was to identify and determine antimicrobial resistance phenotypes and drug resistance genes of clinical coagulase-negative staphylococci (CoNS) isolates at Mae Sot Hospital in Tak province, Thailand. A total of 229 CoNS isolates were collected from clinical specimens during two periods in 2014 and in 2015. Staphylococcus haemolyticus was the most prevalent species (37.55%), followed by S. epidermidis (21.83%), S. saprophyticus (11.79%) and S. hominis (11.35%) respectively. The remaining 17.48% of the organisms comprised S. capitis, S. arlettae, S. cohnii, S. equorum, S. xylosus, S. warneri, S. sciuri, S. pettenkoferi, S. kloosii and S. lugdunensis. Methicillin-resistant CoNS (MRCoNS), containing the mecA gene, were detected in 145 of 229 isolates, mostly found in S. haemolyticus and S. epidermidis. In addition, the differentiation of their macrolide-lincosamide-streptogramin B (MLS"B) resistance phenotypes was determined by the D-test and corresponding resistance genes. Among 125 erythromycin-resistant CoNS, the prevalence of constitutive type of MLS"B, inducible clindamycin resistance and macrolide-streptogramin B resistance phenotypes were 72, 13.60 and 14.40% respectively. These phenotypes were expressed in 80% of MRCoNS strains. In addition, the ermC gene (79.20%) was found to be more prevalent than the ermA gene (22.40%), especially among MRCoNS. These results indicate that CoNS may play an important role in spreading of drug resistance genes. More attention to these organisms in surveillance and monitoring programs is needed.
机译：金黄色葡萄球菌是医院感染和败血症的主要原因。但是，增加耐药性已成为微生物学家的挑战。这项研究的目的是鉴定和确定泰国来兴府湄索医院临床凝固酶阴性葡萄球菌（CoNS）分离株的抗菌素耐药表型和耐药基因。在2014年和2015年的两个阶段中，共从临床标本中收集了229株CoNS分离株。溶血葡萄球菌是最流行的物种（37.55％），其次是表皮葡萄球菌（21.83％），腐生葡萄球菌（11.79％）和人沙门氏菌（11.35％）分别为。其余的17.48％的生物体包括头孢葡萄球菌，拟南芥链球菌，cohnii链球菌，equequum链球菌，xylosus链球菌，warneri链球菌，sciuri链球菌，pettenkoferi链球菌，kloosii链球菌和lugdunensis链球菌。含有mecA基因的耐甲氧西林的CoNS（MRCoNS）在229个分离物中的145个中被检测到，其中大多数在溶血链球菌和表皮葡萄球菌中发现。此外，通过D-检验和相应的耐药基因确定了它们对大环内酯-林可酰胺-链霉菌素B（MLS“ B）耐药表型的分化。在125株对红霉素耐药的CoNS中，本构型MLS” B的发生率是可诱导的克林霉素耐药性和大环内酯类-链霉菌素B耐药性表型分别为72％，13.60％和14.40％。这些表型在80％的MRCoNS菌株中表达。另外，特别是在MRCoNS中，发现ermC基因（79.20％）比ermA基因（22.40％）更普遍。这些结果表明，CoNS可能在耐药基因的传播中起重要作用。需要在监视和监视程序中更多地关注这些生物。

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