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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Acute Administration of Methionine Affects Performance of Swiss Mice in Learning and Memory Paradigms
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Acute Administration of Methionine Affects Performance of Swiss Mice in Learning and Memory Paradigms

机译：急性施用蛋氨酸会影响瑞士小鼠在学习和记忆方面的表现

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Summary: Methionine, an essential amino acid, plays an essential role in the central nervous system CNS development. It serves as a crucial intermediate in the methylation, trans-sulfuration and amino- phosphorylation pathways, necessary for the synthesis of nucleic acids, phospholipids, hormones, neurotransmitters, antioxidants, polyamines, catecholamines and other biogenic amines. The effect of methionine on learning and memory in mice was investigated using Morris water maze (MWM), Elevated plus maze(EPM) and Y maze (YM). Animals were administered with distilled water (control), methionine (1,700mg/kg); folate (3mg/kg) or methionine (1700mg/kg) plus folate (3mg/kg) for 14 days. Escape latency and time spent in target quadrants; transfer latency and percentage spontaneous alternations were measured in the MWM, EPM and YM respectively. The animals were anaesthetized with inhalational chloroform and their brains subsequently harvested, homogenized and assayed for acetylcholinesterase24 hours after the experiment. Folate significantly(p&0.05) increased transfer latency (53.33 ± 12.62) as compared to control (20.1 ± 5.01) and reduced spontaneous alternations significantly (25.0 ± 8.9) when compared to control (44.33 ± 3.07). When folate was combined with methionine there was also a significant increase in transfer latency (43.0 ± 14.39) when compared with control (20.1 ± 5.01). Folate-methionine combination also significantly (p&0.05) reduced spontaneous alternations (20.4 ± 8.4) as compared to the control (44.33 ± 3.07) much more than folate alone. Acetylcholinesterase activities in all groups were not statistically significant. It can be concluded that acute methionine administration has some benefits in memory enhancement. However, a short course folate supplementation impairslearning and working memory especially when combined with methionine which may be as a result of sudden overwhelming of the methylation cycle, leading to homocysteinemia which is pro-dementia. Keywords: Methionine, Memory, Learning, MWM, EPM, Y-Maze
机译：简介：蛋氨酸是一种必需氨基酸，在中枢神经系统中枢神经系统发育中起着重要作用。它是甲基化，反式硫化和氨基磷酸化途径中的关键中间体，是合成核酸，磷脂，激素，神经递质，抗氧化剂，多胺，儿茶酚胺和其他生物胺所必需的。使用莫里斯水迷宫（MWM），高架迷宫（EPM）和Y迷宫（YM）研究了蛋氨酸对小鼠学习和记忆的影响。给动物注射蒸馏水（对照），蛋氨酸（1,700mg / kg）;叶酸（3mg / kg）或蛋氨酸（1700mg / kg）加叶酸（3mg / kg），持续14天。转义潜伏期和目标象限所花费的时间;在MWM，EPM和YM中分别测量了传输潜伏期和自发交替百分比。实验后24小时，用吸入氯仿麻醉动物，然后收集它们的大脑，匀浆并测定其乙酰胆碱酯酶。与对照（20.1±5.01）相比，叶酸显着（p ＜0.05）增加了转移潜伏期（53.33±12.62），与对照（44.33±3.07）相比显着降低了自发交替（25.0±8.9）。当叶酸与蛋氨酸结合使用时，与对照组（20.1±5.01）相比，转移潜伏期也显着增加（43.0±14.39）。与对照（44.33±3.07）相比，叶酸-蛋氨酸的组合还显着（p ＜0.05）减少了自发交替（20.4±8.4），远多于单独的叶酸。所有组的乙酰胆碱酯酶活性均无统计学意义。可以得出结论，急性甲硫氨酸给药在记忆增强中有一些好处。然而，短期补充叶酸会损害学习和工作记忆，特别是与甲硫氨酸合用时，这可能是由于甲基化周期突然不堪重负，导致高半胱氨酸血症，这是痴呆症。关键字：蛋氨酸，记忆，学习，MWM，EPM，Y迷宫

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