...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
【24h】

Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts

机译：非编码RNA聚合酶II转录本对核仁装配的调控

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The nucleolus is a nuclear subcompartment for tightly regulated rRNA production and ribosome subunit biogenesis. It also acts as a cellular stress sensor and can release enriched factors in response to cellular stimuli. Accordingly, the content and structure of the nucleolus change dynamically, which is particularly evident during cell cycle progression: the nucleolus completely disassembles during mitosis and reassembles in interphase. Although the mechanisms that drive nucleolar (re)organization have been the subject of a number of studies, they are only partly understood. Recently, we identified Alu element-containing RNA polymerase II transcripts (alu RNAs) as important for nucleolar structure and rRNA synthesis. Integrating these findings with studies on the liquid droplet-like nature of the nucleolus leads us to propose a model on how RNA polymerase II transcripts could regulate the assembly of the nucleolus in response to external stimuli and during cell cycle progression.
机译：核仁是严格调控rRNA产生和核糖体亚基生物发生的核亚室。它还充当细胞应激传感器，并可以响应细胞刺激释放丰富的因子。因此，核仁的含量和结构是动态变化的，这在细胞周期进程中尤为明显：核仁在有丝分裂期间完全分解，并在相间重新组装。尽管驱动核仁（重组）组织的机制已成为许多研究的主题，但对它们的了解仅是部分的。最近，我们确定了含有Alu元素的RNA聚合酶II转录本（alu RNA）对于核仁结构和rRNA合成很重要。将这些发现与对核仁的液滴样性质的研究相结合，使我们提出了一个模型，该模型涉及RNA聚合酶II转录本如何响应外界刺激以及在细胞周期进程中调节核仁的装配。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号