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LINC complexes in health and disease

机译：LINC复合物在健康和疾病中的应用

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The cell nucleus communicates with the rest of the cell via nucleo/cytoplasmic transport of proteins and RNA through the nuclear pores. Direct mechanical links between the nucleus and the cytoplasm have recently emerged in the form of LINC (LInkers of the Nucleoskeleton to the Cytoskeleton) protein complexes. A LINC complex consists of four components. At its core are an inner nuclear membrane (INM) transmembrane protein and an outer nuclear membrane (ONM) transmembrane protein which physically interact with each other in the lumen of the NE. The INM LINC component interacts on the nucleoplasmic side with either the lamina or with an INM-associated protein. The ONM LINC component on the other hand contacts on the cytoplasmatic side a component of the cytoskeleton. This review highlights the components of LINC complexes and their emerging roles in mechanotransduction, nuclear migration, chromosome positioning, signaling, meiosis, cytoskeletal organization and human disease.
机译：细胞核通过蛋白质和RNA通过核孔的核/胞质运输与细胞的其余部分通信。核与细胞质之间的直接机械联系最近以LINC（核骨架至细胞骨架的线性）蛋白复合物的形式出现。 LINC复合体包含四个组件。其核心是内核膜（INM）跨膜蛋白和外核膜（ONM）跨膜蛋白，它们在NE的内腔中彼此物理相互作用。 INM LINC组件在核质侧与椎板或与INM相关的蛋白质相互作用。另一方面，ONM LINC组分在细胞质侧接触细胞骨架的组分。这篇综述重点介绍了LINC复合物的组成及其在机械转导，核迁移，染色体定位，信号传导，减数分裂，细胞骨架组织和人类疾病中的新兴作用。

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