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Nausea, Vomiting and Retching of Patients with Cervical Cancer undergoing Chemotherapy in Bali, Indonesia

机译:印度尼西亚巴厘岛正在接受化疗的宫颈癌患者的恶心,呕吐和抽搐

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Background: Nausea, vomiting and retching (NVR) was the frequently reported and troublesome adverse effect for patients receiving chemotherapy. Purpose: This study is a part of a larger study which aims to describe the NVR symptom experience in cervical cancer patients undergoing chemotherapy in Bali, Indonesia, and examine relationships with individual's risk factors. Method: Sixty-six patients with stage II and III cervical cancer receiving Paxus (Paclitaxel)-Cisplatin at the second or the third cycle were enrolled. NVR was measured by the Index of Nausea, Vomiting and Retching (INVR) at the second day of their chemotherapy. This current study included only patients with age ranged between 32 to 65 years (M = 47.15, SD = 9.64, min-max age 35 – 65 years). Result: The result showed that the NVR score was at a moderate level. Younger subjects (age 32-50 years old) reported significantly higher NVR scores than that of older subjects (age 51-65 years old) (t = 2.76, p = .007). The subjects with higher anxiety scores reported significantly higher NVR scores than those with lower anxiety scores (t = -2.41, p = .019). Subjects who had experience in motion sickness had significantly higher NVR scores (M = 12.69, SD = 2.60) than those who did not (M = 9.23, SD = 2.86) and the difference was statistically significant (t = 4.98, p <.01). Meanwhile, no significant difference was found between subjects who reported their expectation to have nausea and those who did not (t = 0.08, p = .94). Conclusion: The findings provide valuable information regarding NVR and the individual risk factors among patients with cervical cancer undergoing chemotherapy. Nurses should assess the anxiety level and a history of motion sickness of patients planned for chemotherapy and offer preventive interventions to prevent and control NVR occurrence and its distress.
机译:背景:恶心,呕吐和呕吐(NVR)是接受化疗的患者经常发生的不良反应。目的:本研究是一项大型研究的一部分,旨在描述印度尼西亚巴厘岛接受化疗的宫颈癌患者的NVR症状经历,并研究其与个人危险因素的关系。方法:纳入第二或第三周期接受Paxus(Paclitaxel)-Cisplatin治疗的II期和III期宫颈癌的66例患者。 NVR是在化疗第二天通过恶心,呕吐和抓痒指数(INVR)进行测量的。本研究仅包括年龄在32至65岁之间的患者(M = 47.15,SD = 9.64,最小-最大年龄35-65岁)。结果:结果表明,NVR得分处于中等水平。较年轻的受试者(32-50岁)报告的NVR得分明显高于较老的受试者(51-65岁)(t = 2.76,p = .007)。焦虑评分较高的受试者报告的NVR评分明显高于焦虑评分较低的受试者(t = -2.41,p = .019)。经历过晕动病的受试者的NVR得分(M = 12.69,SD = 2.60)明显高于未经历运动的受试者(M = 9.23,SD = 2.86),差异具有统计学意义(t = 4.98,p <.01 )。同时,在报告有恶心预期的受试者和没有恶心的受试者之间未发现显着差异(t = 0.08,p = .94)。结论:这些发现为宫颈癌患者化疗中的NVR和个体危险因素提供了有价值的信息。护士应评估计划进行化疗的患者的焦虑程度和晕车病史,并提供预防性干预措施,以预防和控制NVR的发生及其困扰。

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