Nuclear lamins

Eivind Lund; Philippe Collas

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Nuclear lamins

机译：核纤层蛋白

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The nuclear lamina guards the genome and in many ways contributes to regulating nuclear function. Increasing evidence indicates that the lamina dynamically interacts with chromatin mainly through large repressive domains, and recent data suggest that at least some of the lamin-genome contacts may be developmentally significant. In an attempt to provide an additional meaning to lamin-genome contacts, a recent study characterized the association of gene promoters with A-type lamins in progenitor and differentiated cells. Here, we discuss how A-type lamins interact with spatially defined promoter regions, and the relationship between these interactions, associated chromatin marks and gene expression outputs. We discuss the impact of A-type lamins on nucleus-wide and local chromatin organization. We also address how lamin-promoter interactions are redistributed during differentiation of adipocyte progenitors into adipocytes. Finally, we propose a model of lineage-specific “unlocking” of developmentally regulated loci and its significance in cellular differentiation.

机译：核薄层保护基因组，并在许多方面有助于调节核功能。越来越多的证据表明，层板主要通过大的阻遏域与染色质动态相互作用，最近的数据表明，至少部分层状基因组接触可能具有重要的发展意义。为了给lamin-基因组接触提供额外的含义，最近的一项研究对祖细胞和分化细胞中基因启动子与A型lamins的关联进行了表征。在这里，我们讨论A型lamins如何与空间定义的启动子区域相互作用，以及这些相互作用，相关的染色质标记和基因表达输出之间的关系。我们讨论了A型核纤层蛋白对全核和局部染色质组织的影响。我们还讨论了如何在脂肪细胞祖细胞分化为脂肪细胞的过程中重新分配椎板启动子相互作用。最后，我们提出了一个沿袭特定的“解开”发育调控基因座的模型及其在细胞分化中的意义。

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《Nucleus》 |2013年第6期|共7页
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Eivind Lund; Philippe Collas;
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中图分类细胞生物学;
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1. B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis [J] . Yoshihiro H. Inoue, Hiroka Katsube, Karin Tanabe, Biology Open . 2016,第8期

机译：B型核纤层蛋白和核孔复合物Nup107-160影响维持果蝇雄性减数分裂所需的纺锤体包膜B型核纤溶蛋白和核孔复合物Nup107-160影响维持果蝇进行胞质分裂所需的纺锤体包膜雄性减数分裂B型核层蛋白和核孔复合体Nup107-160影响果蝇雄性减数分裂胞质分裂所需的纺锤体包膜的维持
2. The fates of chicken nuclear lamin proteins during mitosis: evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum. [J] . R Stick, B Angres, C F Lehner, Journal of cell biology . 1988,第2期

机译：鸡核核纤层蛋白在有丝分裂过程中的命运：核纤层蛋白B2在内核膜和内质网元素之间可逆的重新分布的证据。
3. Identification of distinct messenger RNAs for nuclear lamin C and a putative precursor of nuclear lamin A. [J] . J F Laliberté, A Dagenais, M Filion, Journal of cell biology . 1984,第3期

机译：鉴定核纤层蛋白C和推定的核纤层蛋白A的不同信使RNA。
4. Nuclear lamins: building blocks of nuclear structure and function [C] . Robert D. Goldman, Anne E. Goldman, Dale K. Shumake Novartis Foundation symposium on Nuclear organization in development and disease . 2005

机译：核叠层：构建核结构块和功能
5. Nuclear Membrane Ruptures in the Setting of Nuclear Lamin Deficiencies [D] . Chen, Natalie Yunwen. 2021

机译：核膜破裂在核填充物的环境中
6. Fate of the Inner Nuclear Membrane Protein Lamin B Receptor and Nuclear Lamins in Herpes Simplex Virus Type 1 Infection [O] . Emily S. Scott, Peter OHare 2001

机译：单纯疱疹病毒1型感染中的内核膜蛋白lamin B受体和核lamins的命运。
7. Characterisation of the molecular links between the nuclear pore complex and the nuclear lamins and reconstitution of the "Xenopus" oocyte lamin assembly "in vitro" [O] . Al-Haboubi Teiba 2009

机译：表征核孔复合物和核纤层蛋白之间的分子联系和“非洲爪蟾”卵母细胞核纤层组件“体外”的重建

Nuclear lamins

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