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PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation

机译：PML核体：组装和氧化应激敏感的磺酰化

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摘要

PML Nuclear Bodies (NBs) have fascinated cell biologists due to their exquisitely dynamic nature and their involvement in human diseases, notably acute promyelocytic leukemia. NBs, as well as their master organizer - the PML protein - exhibit multiple connections with stress responses. Initially viewed as a tumor suppressor, PML recently re-emerged as a multifaceted protein, capable of controlling numerous aspects of cellular homeostasis. NBs recruit many functionally diverse proteins and function as stress-regulated sumoylation factories. SUMO-initiated partner retention can subsequently facilitate a variety of other post-translational modifications, as well as partner degradation. With this newly elucidated central role of stress-enhanced sumoylation, it should now be possible to build a working model for the different NB-regulated cellular activities. Moreover, pharmacological manipulation of NB formation by interferons or oxidants holds the promise of clearing many undesirable proteins for clinical management of malignant, viral or neurodegenerative diseases.
机译：由于PML核体（NBs）的动态特性以及与人类疾病（尤其是急性早幼粒细胞白血病）的密切相关，它们使细胞生物学家着迷。 NB及其主要组织者PML蛋白在压力反应中表现出多种联系。 PML最初被视为一种肿瘤抑制因子，最近又作为一种多面蛋白重新出现，能够控制细胞动态平衡的许多方面。 NB募集许多功能多样的蛋白质，并充当应激调节的磺酰化工厂。 SUMO启动的伴侣保留可以随后促进多种其他翻译后修饰以及伴侣降解。通过这种新近阐明的应力增强的磺酰化的中心作用，现在应该可以为不同的NB调节的细胞活动建立一个工作模型。而且，由干扰素或氧化剂对NB形成的药理学操纵有望清除许多不良蛋白质，用于临床治疗恶性，病毒或神经退行性疾病。

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