首页> 外文期刊>Nucleus >Regulation of active genome integrity and expression by Rad26p
【24h】

Regulation of active genome integrity and expression by Rad26p

机译:Rad26p对活性基因组完整性和表达的调控

获取原文
           

摘要

Rad26p is a SWI/SNF-like ATPase in yeast, and is conserved among eukaryotes. Both Rad26p and its human homolog CSB (Cockayne syndrome group B) are involved in regulation of chromatin structure, transcription and DNA repair.??Thus, mutations or malfunctions of these proteins have significant effects on cellular functions. Mutations in CSB are associated with Cockayne syndrome (CS) that is characterized by heterogeneous pathologies such as mental and physical retardation, sun sensitivity, premature aging, muscular and skeletal abnormalities, and progressive decline in neurological and cognitive functions. Therefore, many research groups focused their studies to understand the mechanisms of Rad26p/CSB functions to illuminate the molecular bases of CS. These studies have provided significant functional and mechanistic insights of Rad26p/CSB in regulation of gene expression and genome integrity as described here.
机译:Rad26p是酵母中的SWI / SNF样ATPase,在真核生物中是保守的。 Rad26p及其人类同源CSB(Cockayne综合征B组)均参与染色质结构的调控,转录和DNA修复。因此,这些蛋白质的突变或功能异常对细胞功能具有重要影响。 CSB中的突变与Cockayne综合征(CS)有关,其特征是异质性病理,例如精神和身体发育迟缓,阳光敏感性,过早衰老,肌肉和骨骼异常以及神经和认知功能的逐步下降。因此,许多研究小组将他们的研究重点放在了解Rad26p / CSB功能阐明CS分子基础的机制上。这些研究提供了Rad26p / CSB在调控基因表达和基因组完整性方面的重要功能和机理见解,如下所述。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号