Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters

Ping Chen; Yan Wang; Guohong Li

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Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters

机译：组蛋白变体H3.3的动力学及其在增强子和启动子上与H2A.Z的共调控

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In eukaryotes, genomic DNA is hierarchically packaged into chromatin by histones. A defined organization of the genome into chromatin with specific patterns of epigenetic modifications is crucial for transcriptional regulation, cell fate determination, and maintenance, in which the histone variant incorporation has been characterized as one of the most key players. The diversity of histone variants results in structural plasticity of chromatin and highlights functionally distinct chromosomal domains. Here we focus on the role of histone variant H3.3 and its coregulation with H2A.Z in chromatin dynamics at enhancers and promoters and transcriptional regulation.

机译：在真核生物中，基因组DNA通过组蛋白被层次化包装到染色质中。基因组到染色质的明确组织与表观遗传修饰的特定模式对于转录调控，细胞命运确定和维持至关重要，其中组蛋白变体掺入已被认为是最关键的参与者之一。组蛋白变体的多样性导致染色质的结构可塑性，并突出了功能上不同的染色体结构域。在这里，我们着眼于组蛋白变体H3.3的作用及其与H2A.Z的共调节作用，在增强子和启动子的染色质动力学中以及转录调控方面。

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《Nucleus》 |2014年第1期|共7页
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Ping Chen; Yan Wang; Guohong Li;
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中图分类细胞生物学;
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1. Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters [J] . Ping Chen, Yan Wang, Guohong Li Nucleus . 2014,第1期

机译：组蛋白变体H3.3的动力学及其在增强子和启动子上与H2A.Z的共调控
2. Transcription outcome of promoters enriched in histone variant H3.3 defined by positioning of H3.3 and local chromatin marks [J] . Lund Eivind G., Collas Philippe, Delbarre Erwan Biochemical and Biophysical Research Communications . 2015,第2期

机译：通过定位H3.3和局部染色质标记定义的组蛋白变体H3.3中富集的促进剂的转录结果
3. Transcription outcome of promoters enriched in histone variant H3.3 defined by positioning of H3.3 and local chromatin marks [J] . Lund Eivind G., Collas Philippe, Delbarre Erwan Biochemical and Biophysical Research Communications . 2015,第2期

机译：通过定位H3.3和局部染色质标记而定义的富含组蛋白变体H3.3的启动子的转录结果
4. Global dynamics of nucleosome arrays: influence of variant histone H2A.Z [C] . Li Wang, Ramaswamy, A., . 2005

机译：核小体阵列的全球动力学：变异组蛋白H2A.Z的影响
5. Investigating the Role of Histone Variant H2A.Z in Brown Adipogenesis [D] . Macdonald, Stephanie A. 2019

机译：研究组蛋白变体H2A.Z在棕色脂肪形成中的作用
6. Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters [O] . Ping Chen, Yan Wang, Guohong Li 2014

机译：组蛋白变体H3.3的动力学及其在增强子和启动子上与H2A.Z的共调控
7. H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions [O] . Chunyuan Jin, Chongzhi Zang, Gang Wei, 2009

机译：H3.3 / H2A.z含双变体的核肉标记的活性启动子和其他调节区的“无核细胞区”

Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters

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