• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >Nucleolus Precursor Body (NPB): A Distinct Structure in Mammalian Oocytes and Zygotes
【24h】

Nucleolus Precursor Body (NPB): A Distinct Structure in Mammalian Oocytes and Zygotes

机译：核仁前体（NPB）：哺乳动物卵母细胞和合子中的不同结构。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nucleoli in mammalian oocytes and zygotes, sometimes referred to as nucleolus precursor bodies (NPBs), are compact and morphologically different from nucleoli in somatic cells. We applied a unique NPB analyzing method “enucleolation” technique to zygotes to remove the NPBs. It has been reported that oocyte NPBs are essential for embryonic development; in their absence, the oocytes complete maturation and can be fertilized, but no nucleoli are formed in the zygotes and embryos, leading to developmental failure. However, we found that when NPBs were removed from zygotes, the zygotes developed successfully to live-born pups. These results indicated that oocyte NPBs are essential for embryonic development, but zygote NPBs are not. In addition, the enucleolated zygotes formed somatic-type nucleoli during early embryonic development, demonstrating that somatic-type nucleoli do not originate from zygote NPBs. We summarize our recent investigation on NPBs, and provide additional comments and findings.
机译：哺乳动物卵母细胞和受精卵中的核仁有时被称为核仁前体（NPB），其结构紧凑，形态上不同于体细胞中的核仁。我们将独特的NPB分析方法“ enucleolation”技术应用于合子以去除NPB。据报道，卵母细胞NPB对于胚胎发育是必不可少的。在没有卵母细胞的情况下，卵母细胞可以完全成熟并可以受精，但是在受精卵和胚胎中没有形成核仁，从而导致发育失败。但是，我们发现，当从合子中去除NPB时，合子成功地发育为活体幼崽。这些结果表明卵母细胞NPB对于胚胎发育是必不可少的，但是合子NPB不是。此外，在早期胚胎发育过程中，被核苷酸化的受精卵形成了体细胞型核仁，这表明体细胞型核仁不是源自合子NPB。我们总结了最近对NPB的调查，并提供了其他评论和发现。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号