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首页> 外文期刊>Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction >Nucleolus Precursor Bodies and Ribosome Biogenesis in Early Mammalian Embryos: Old Theories and New Discoveries
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Nucleolus Precursor Bodies and Ribosome Biogenesis in Early Mammalian Embryos: Old Theories and New Discoveries

机译：哺乳动物早期胚胎的核仁前体和核糖体的生物发生：旧理论和新发现。

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摘要

In mammals, mature oocytes and early preimplantation embryos contain transcriptionally inactive structures termed nucleolus precursor bodies instead of the typical fibrillogranular nucleoli. These nuclear organelles are essential and strictly of maternal origin. If they are removed from oocytes, the resulting embryos are unable to replace them and consequently fail to develop. Historically, nucleolus precursor bodies have been perceived as a passive repository site of nucleolar proteins that are required for embryos to form fully functional nucleoli. Recent results, however, contradict this long-standing dogma and show that these organelles are dispensable for nucleologenesis and ribosome biogenesis. In this article, we discuss the possible roles of nucleolus precursor bodies and propose how they might be involved in embryogenesis. Furthermore, we argue that these organelles are essential only shortly after fertilization and suggest that they might actively participate in centromeric chromatin establishment.
机译：在哺乳动物中，成熟的卵母细胞和早期植入前胚胎包含称为核仁前体的转录无活性结构，而不是典型的原纤维状核仁。这些核细胞器是必不可少的，并且严格来说是产妇的来源。如果将它们从卵母细胞中去除，则所得的胚胎将无法替代它们，因此无法发育。从历史上看，核仁前体被视为核仁蛋白的被动贮藏位点，这是胚胎形成功能齐全的核仁所必需的。然而，最近的结果与这种长期存在的教条相矛盾，并且表明这些细胞器对于核发生和核糖体生物发生是必不可少的。在本文中，我们讨论了核仁前体的可能作用，并提出了它们可能如何参与胚胎发生。此外，我们认为这些细胞器仅在受精后不久才是必需的，并暗示它们可能会积极参与着丝粒染色质的建立。

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