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首页> 外文期刊>Nutrition Metabolism >Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study
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Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study

机译：肥胖儿童的饮食限制及其与饮食行为，成纤维细胞生长因子21和瘦素的关系：前瞻性临床干预研究

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Background Obesity is significant problem involving eating behavior and peripheral metabolic conditions. The effect of carbohydrate and fat restriction on appetite regulation, fibroblast growth factor 21 (FGF21) and leptin in children has not been defined. Our objective was to compare the effect of both diets. Methods One hundred and twenty children with body mass index (BMI) higher than the equivalent of 30 kg/m 2 for an adult, as corrected for gender and age were randomly assigned to (n?=?60) a low-carbohydrate (L-CHO) diet or (n?=?60) a low-fat (L-F) diet for 2 months. Fifty-three (88.3 %) subjects on the low-carbohydrate-diet and 45 (75 %) on the low-fat diet completed the study. Anthropometric measures, leptin and FGF21 levels were measured before and after the intervention. Comparison of the data for both of the diet groups was carried out using the t-test for independent variables. Intragroup comparisons before and after of each of the dietary treatments were performed using ANOVA for repeated measures. Factors associated with FGF21, leptin levels and satiety, were analyzed by multiple regression. Results After both of the diets, weight, leptin, food responsiveness, and enjoyment of food significantly decreased and high density lipoprotein cholesterol (HDL) increased, but FGF21 decreased. Before and after both of the interventions FGF21 was associated with triglycerides. Before the diet, satiety was associated with lower screen time (p?
机译：背景技术肥胖是涉及饮食行为和周围代谢状况的重大问题。尚未确定碳水化合物和脂肪限制对儿童食欲调节，成纤维细胞生长因子21（FGF21）和瘦素的影响。我们的目的是比较两种饮食的效果。方法将经性别和年龄校正的120名体重指数（BMI）高于成人等效体重30 kg / m 2的儿童随机分配（n？=？60）低碳水化合物（L） -CHO）饮食或（n？=？60）低脂（LF）饮食2个月。低碳水化合物饮食的53名受试者（88.3％）和低脂饮食的45名受试者（75％）完成了研究。干预前后测量人体测量指标，瘦素和FGF21水平。使用t检验对独立变量进行两个饮食组数据的比较。使用ANOVA进行重复测量，对每种饮食治疗前后的组内比较。通过多元回归分析与FGF21，瘦素水平和饱腹感相关的因素。结果两种饮食后，体重，瘦素，食物反应性和食物享受均显着降低，高密度脂蛋白胆固醇（HDL）升高，而FGF21降低。两种干预前后，FGF21与甘油三酸酯相关。在饮食之前，饱腹感与较低的筛查时间（p 0.04）和胰岛素水平（p 0.05）相关。结论两种饮食限制均可改善肥胖儿童的代谢和激素水平。 FGF21是年幼儿童有益代谢反应的指标。 2个月后，观察到饮食行为适应食物限制。

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