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The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias

机译：FLT3突变对急性髓细胞性白血病发展的影响

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The development of the genetic studies on acute myeloid leukemias (AMLs) has led to the identification of some recurrent genetic abnormalities. Their discovery was of fundamental importance not only for a better understanding of the molecular pathogenesis of AMLs, but also for the identification of new therapeutic targets. In this context, it is essential to identify AML-associated “driver” mutations, which have a causative role in leukemogenesis. Evidences accumulated during the last years indicate that activating internal tandem duplication mutations in FLT3 (FLT3-ITD), detected in about 20% of AMLs, represents driver mutations and valid therapeutic targets in AMLs. Furthermore, the screening of FLT3-ITD mutations has also considerably helped to improve the identification of more accurate prognostic criteria and of the therapeutic selection of patients.
机译：急性髓性白血病（AML）的遗传学研究的发展已导致鉴定出一些复发性遗传异常。他们的发现不仅对于更好地了解AML的分子发病机理，而且对于确定新的治疗靶点都具有根本的重要性。在这种情况下，至关重要的是要确定与AML相关的“驱动程序”突变，这些突变在白血病的发生中具有致病作用。过去几年中积累的证据表明，在大约20％的AML中检测到激活的FLT3内部串联重复突变（FLT3-ITD）代表了AML中的驱动程序突变和有效的治疗靶标。此外，FLT3-ITD突变的筛选也大大有助于改善对更准确的预后标准的鉴定和对患者的治疗选择。

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