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首页> 外文期刊>Nutrients >Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice
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Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice

机译：朝鲜蓟（一种可食用的草药）的乙醇提取物对小鼠急性酒精性肝损伤的保护作用

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Oxidative stress and inflammation are well-documented pathological factors in alcoholic liver disease (ALD). Artichoke ( Cynara scolymus L.) is a healthy food and folk medicine with anti-oxidative and anti-inflammatory properties. This study aimed to evaluate the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice. Male Institute of Cancer Research mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily. Up to 40% alcohol (12 mL/kg body weight) was administered orally 1 h after artichoke treatment. All mice were fed for 10 consecutive days. Results showed that artichoke extract significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, triglyceride, total cholesterol, and malondialdehyde. Meanwhile, the decreased levels of superoxide dismutase and glutathione were elevated by artichoke administration. Histopathological examination showed that artichoke attenuated degeneration, inflammatory infiltration and necrosis of hepatocytes. Immunohistochemical analysis revealed that expression levels of toll-like receptor (TLR) 4 and nuclear factor-kappa B (NF-κB) in liver tissues were significantly suppressed by artichoke treatment. Results obtained demonstrated that artichoke extract exhibited significant preventive protective effect against acute alcohol-induced liver injury. This finding is mainly attributed to its ability to attenuate oxidative stress and suppress the TLR4/NF-κB inflammatory pathway. To the best of our knowledge, the underlying mechanisms of artichoke on acute ALD have been rarely reported.
机译：氧化应激和炎症是酒精性肝病（ALD）中有充分文献记载的病理因素。朝鲜蓟（Cynara scolymus L.）是一种具有抗氧化和抗炎特性的健康食品和民间药物。这项研究旨在评估朝鲜蓟乙醇提取物对小鼠急性酒精性肝损伤的预防作用。每天一次用管饲法用朝鲜蓟乙醇提取物（0.4、0.8和1.6 g / kg体重）处理雄性癌症研究所的小鼠。朝鲜蓟治疗后1 h口服高达40％的酒精（12 mL / kg体重）。将所有小鼠连续喂养10天。结果表明，朝鲜蓟提取物显着阻止了天冬氨酸转氨酶，丙氨酸转氨酶，甘油三酸酯，总胆固醇和丙二醛水平的升高。同时，朝鲜蓟施用增加了超氧化物歧化酶和谷胱甘肽的降低水平。组织病理学检查显示朝鲜蓟减弱了肝细胞的变性，炎性浸润和坏死。免疫组织化学分析显示，朝鲜蓟治疗可显着抑制肝脏组织中Toll样受体（TLR）4和核因子-κB（NF-κB）的表达水平。获得的结果表明，朝鲜蓟提取物对急性酒精引起的肝损伤显示出显着的预防性保护作用。这一发现主要归因于其减轻氧化应激和抑制TLR4 /NF-κB炎症途径的能力。据我们所知，朝鲜蓟对急性ALD的潜在机制鲜有报道。

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