Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies

Bo?ena Cukrowska

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Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies

机译：微生物和营养程序设计—微生物组的重要性以及在过敏症发展中及早暴露于潜在的食物过敏原

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The “microbiota hypothesis” ties the increase in allergy rates observed in highly developed countries over the last decades to disturbances in the gut microbiota. Gut microbiota formation depends on a number of factors and occurs over approximately 1000 days of life, including the prenatal period. During this period the microbiota helps establish the functional immune phenotype, including immune tolerance. The development of immune tolerance depends also on early exposure to potential food allergens, a process referred to as nutritional programming. This article elaborates on the concepts of microbial and nutritional programming and their role in the primary prevention of allergy.

机译：“微生物群假说”将近几十年来在高度发达国家中观察到的过敏率增加与肠道微生物群的紊乱联系起来。肠道菌群的形成取决于许多因素，并在大约1000天的生命中发生，包括产前时期。在此期间，微生物群有助于建立功能性免疫表型，包括免疫耐受性。免疫耐受的发展还取决于尽早暴露于潜在的食物过敏原，这一过程被称为营养程序。本文详细介绍了微生物和营养程序设计的概念及其在过敏原预防中的作用。

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《Nutrients》 |2018年第10期|共12页
作者
Bo?ena Cukrowska;
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中图分类预防医学、卫生学;
关键词
microbiomeintestinal microbiotamicrobial programmingnutritional programmingallergyprevention;

机译：微生物肠道微生物菌群编程营养编程防过敏;

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1. Timing of allergen exposure and the development of food allergy: treating before the horse is out of the barn [J] . Elizur Arnon, Katz Yitzhak SIAM journal on applied dynamical systems . 2017,第2期

机译：过敏原暴露的时间和食物过敏的发展：在马之前对谷仓进行治疗
2. Timing of allergen exposure and the development of food allergy: treating before the horse is out of the barn [J] . Elizur Arnon, Katz Yitzhak Current opinion in allergy and clinical immunology . 2016,第2期

机译：过敏原暴露的时间和食物过敏的发展：在马离开谷仓之前进行治疗
3. Immune status of the mother and early exposure through breastfeeding both influence the protection of the progeny from food allergy development to a major cow’s milk allergen [J] . Karine Adel-Patient, Sandrine Ah-Leung, Hervé Bernard, Clinical and Translational Allergy . 2015,第3期

机译：母亲的免疫状况和通过母乳喂养的早期接触都影响后代对食物过敏和主要牛奶过敏原的保护。
4. Sensitization to food and pollen allergens and their implication for travelers with respiratory allergies [C] . I Rengganis, L S Pakasi Annual Applied Science and Engineering Conference . 2019

机译：对食物和花粉过敏原的敏感及其对呼吸过敏的旅行者的含义
5. Using Bioinformatics Tools to Evaluate Potential Risks of Food Allergy and to Predict Microbiome Functionality [D] . Abdelmoteleb, Mohamed. 2020

机译：使用生物信息学工具来评估食物过敏的潜在风险，并预测微生物组功能
6. Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies [O] . Bożena Cukrowska 2018

机译：微生物和营养计划—微生物组的重要性以及在过敏症发展过程中尽早暴露于潜在的食物过敏原
7. The impact of early-life exposure to food allergens on the subsequent development of sensitisation and allergy to foods [O] . R. L. Thompson, L. M. Miles, J. Lunn, 2010

机译：早期暴露于食品过敏原的影响对随后对食品的致敏和过敏的影响
8. Data Development Initiatives for Research on Food Assistance and Nutrition Program, Phase I: Ten Potential Data Initiatives [R] . Wittenburg, D., Bell, L., Kenyon, A., 2001

机译：粮食援助和营养计划研究数据发展倡议，第一阶段：十项潜在数据举措

Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies

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