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Pharmacoepidemiology – from description to quality assessment. A Swedish perspective

机译:药物流行病学–从描述到质量评估。瑞典的观点

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Parallel with increasing concerns about drug safety, the importance of drug surveillance and the applicationof epidemiological techniques have grown rapidly during the past decades. The increasing use of computerizedhealth care data facilitates the establishment of populations large enough to allow epidemiologicalstudies. By the use of computerized pharmacy or billing records, drug exposure is linked to files whichinclude outcome data (diagnoses). Pioneering pharmacoepidemiology surveys of prescriptions purchasedfrom defined populations were initiated in the late 1960s. Two such population-based drug databases forresearch (J?mtland and Tierp) are still in use in Sweden and can provide key epidemiological data such asincidence and prevalence of drug use by age and sex. This basic information on drug use can only beobtained if there is a personal identifier on the prescription. Important studies such as quality of care, polypharmacy,drug interactions, drug abuse and physicians' prescribing habits all require data on drug use byindividuals. Unfortunately, because of sensitivity to the issue of data confidentiality in Sweden, the correspondinglyrecorded data on prescriptions relative to individual patients is not available for use in healthcare audits or research. With these limitations in access to patient specific data on drug use, focus is nowinstead on improving the quality of drug prescribing by use of available drug statistics. The number ofdrugs that account for 90% of the use – the Drug Utilization 90% segment – and adherence to guidelines inthis segment are now being tested as general indicators for assessing the quality of drug prescribing.
机译:在过去的几十年中,与对药物安全性,药物监测的重要性和流行病学技术的应用的关注日益密切相关。越来越多地使用计算机化的医疗保健数据有助于建立足够大的人群以进行流行病学研究。通过使用计算机化的药房或帐单记录,药物暴露链接到包含结果数据(诊断)的文件。从特定人群购买的处方药的开创性药物流行病学调查始于1960年代后期。瑞典仍在使用两个这样的基于人群的药物研究数据库(J?mtland和Tierp),它们可以提供重要的流行病学数据,例如按年龄和性别划分的吸毒发生率和流行率。仅在处方上有个人识别码时,才能获得有关药物使用的基本信息。重要的研究,例如护理质量,多药店,药物相互作用,药物滥用和医师的处方习惯,都需要个人使用药物的数据。不幸的是,由于瑞典对数据保密性问题比较敏感,因此,有关个人患者处方的相应记录数据无法用于医疗保健审计或研究。由于在访问患者特定药物使用数据方面存在这些限制,因此现在的重点不再是通过使用可用的药物统计数据来提高药物处方的质量。占使用量90%的药物数量(“药物利用率90%”部分)以及该部分对准则的遵守情况正在作为评估药物处方质量的一般指标进行测试。

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