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首页> 外文期刊>Reproductive Biology and Endocrinology >Effects of cumulus cell removal time during in vitro fertilization on embryo quality and pregnancy outcomes: a prospective randomized sibling-oocyte study
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Effects of cumulus cell removal time during in vitro fertilization on embryo quality and pregnancy outcomes: a prospective randomized sibling-oocyte study

机译：体外受精期间积卵去除时间对胚胎质量和妊娠结局的影响：一项前瞻性随机兄弟卵母细胞研究

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Background To investigate whether cumulus cell removal after a 3?h co-incubation of gametes can affect the outcomes of in vitro fertilization. Methods A prospective randomized sibling-oocyte study was performed in which sibling oocytes obtained from each patient were randomly assigned to either a 3?h or 20?h group (cumulus cells removed at 3?h or 20?h after insemination, respectively). Same origin embryos (either 3?h or 20?h) were transferred. The study participants were patients?Results The study enrolled 172 patients, from whom 2275 oocytes were retrieved (1139 oocytes for the 3?h group and 1136 oocytes for the 20?h group). A total of 134 patients received embryo transfers (74 patients in the 3?h group and 60 patients in the 20?h group), and there were 54 live births (32 in the 3?h group and 22 in the 20?h group). When compared with patients in the 20?h group, patients in the 3?h group produced a larger number of optimal quality embryos, but had higher rates of polyspermy and low birth weight newborns. The two groups showed no differences in their rates of normal fertilization, pregnancy, and live birth. Conclusions When compared with results obtained using a traditional cumulus cell removal protocol, early cumulus cell removal has both advantages and disadvantages. Further studies, and especially long-term outcome studies on newborns, need to be performed. Trial registration Current controlled trial ChiCTR-OOC-15006878
机译：背景研究配子共孵育3小时后，去除积卵细胞是否会影响体外受精的结果。方法进行一项前瞻性随机兄弟卵母细胞研究，将每位患者获得的兄弟卵母细胞随机分配到3？h或20？h组（分别在授精后3？h或20？h去除积卵细胞）。移植了相同来源的胚胎（3？h或20？h）。结果参加研究的患者为172名患者，共检索到2275卵母细胞（3？h组为1139卵母细胞，而20？h组为1136卵母细胞）。共有134例患者接受了胚胎移植（3？h组74例，20？h组60例），活产54例（3？h组32例，20？h组22例） ）。与20h组的患者相比，3h组的患者产生了大量最佳质量的胚胎，但是多精子和低出生体重新生儿的发生率更高。两组的正常受精率，妊娠率和活产率均无差异。结论与使用传统的卵丘细胞去除方案获得的结果相比，早期的卵丘细胞去除具有优点和缺点。需要进行进一步的研究，尤其是对新生儿的长期结局研究。试用注册当前对照试验ChiCTR-OOC-15006878

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