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首页> 外文期刊>Research Journal of Medical Sciences >Effect of Angiotensin I-Converting Enzyme Inhibitor, Captopril on Body Weight, Food and Water Consumption in Oral Contraceptive-Treated Rats
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Effect of Angiotensin I-Converting Enzyme Inhibitor, Captopril on Body Weight, Food and Water Consumption in Oral Contraceptive-Treated Rats

机译：血管紧张素转换酶抑制剂卡托普利对口服避孕药大鼠体重，食物和水消耗的影响

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Studies have shown that hormonal changes that occur during menstrual or oestrous cycle influence angiotensin-induced water intake. However, little is known about the effects of Oral Contraceptive (OC) on body weight and eating habit when Renin-Angiotensin System (RAS) is suppressed. This study documents the effect of OC on weight gain and food and water consumption. It also assesses whether suppression of RAS by captopril would affect OC-induced changes. About 40 female rats distributed into 4 groups (10 rats in each) were used for the experiment. Vehicles-treated, OC-treated, captopril-treated and OC + captopril-treated groups. Body weight, food and water intake were recorded daily throughout the experiment period. Food and water consumed per day per 100 g body weight was also calculated. OC-treated and OC + captopril-treated rats had significantly lower body weight when compared with those of vehicle treated and captopril-treated rats. OC-treated rats consumed significantly less food than vehicle-treated and captopril-treated groups. OC + captopril-treated rats consumed significantly less food than other groups but when food consumption was adjusted to body weight, there was significant decrease in food consumption in OC-treated group. OC administration is associated with reduction in weight gain and food and water consumption. Co-administration of captopril significantly augments this effect.
机译：研究表明，在月经或发情周期内发生的激素变化会影响血管紧张素诱导的摄水量。然而，当抑制肾素-血管紧张素系统（RAS）时，口服避孕药（OC）对体重和饮食习惯的影响知之甚少。这项研究记录了OC对体重增加以及食物和水消耗的影响。它还评估了卡托普利抑制RAS是否会影响OC引起的变化。实验将约40只雌性大鼠分为4组（每组10只）。媒介物处理组，OC处理组，卡托普利处理组和OC +卡托普利处理组。在整个实验期间每天记录体重，食物和水的摄入量。还计算了每100克体重每天消耗的食物和水。与载体治疗和卡托普利治疗的大鼠相比，OC处理和OC +卡托普利治疗的大鼠的体重明显降低。 OC处理的大鼠的食物消耗量显着少于媒介物处理组和卡托普利治疗组。 OC +卡托普利治疗的大鼠的食物消耗明显少于其他组，但将食物消耗调整至体重后，OC治疗组的食物消耗显着减少。 OC的管理与体重增加的减少以及食物和水的消耗有关。卡托普利的共同给药显着增强了这种作用。

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