Synthesis and Physico-Chemical Analysis of 3-{[(3, 4-Dimethoxy-Phenyl)-Phenylamino-Methyl]-Amino}-2-Phenyl-Quinazolin-4(3h)-One

Ramesh Dhani; Rajesh K.; P. Mastanaiah

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Synthesis and Physico-Chemical Analysis of 3-{[(3, 4-Dimethoxy-Phenyl)-Phenylamino-Methyl]-Amino}-2-Phenyl-Quinazolin-4(3h)-One

机译：3-{[（3,4-二甲氧基-苯基）-苯基氨基-甲基]-氨基} -2-苯基-喹唑啉-4（3h）-的合成及理化分析

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Medicinal chemistry as practiced encompasses both definitions, but finding the biochemical pathways through which drug exert their beneficial effects has become a dominating activity of the medicinal chemist and biologist while searching for ahead on a new drug or doing research on a pre-clinical drug candidate. Heterocyclic chemistry is the branch of chemistry dealing with the synthesis, properties, and applications of heterocyclics. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. Quinazolinone has been considered as a magic moiety possessing myriad spectrum of medicinal activities. Diversity of biological response profile has attracted considerable interest of several researchers across the globe to explore this skeleton for its assorted therapeutic significance. By using different synthetic methods new quinazolinone derivatives were synthesized and characterized by physic-chemical analysis. Quinazolinone is a lead nucleus for future developments to get effective compounds.

机译：实践中的药物化学涵盖了这两个定义，但是寻找药物发挥其有益作用的生化途径已成为药物化学家和生物学家的主要活动，同时寻找新的药物或对临床前候选药物进行研究。杂环化学是涉及杂环的合成，性质和应用的化学分支。杂环化学至少占全球所有有机化学研究的一半。杂环结构尤其是许多药物，农用化学品和兽医产品的基础。喹唑啉酮被认为是具有无数种药物活性谱的魔术部分。生物反应谱的多样性已经吸引了全球几位研究者的极大兴趣，以探索其骨架的各种治疗意义。通过使用不同的合成方法，合成了新的喹唑啉酮衍生物，并通过理化分析对其进行了表征。喹唑啉酮是未来开发中获得有效化合物的先导核。

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《Research Journal of Pharmaceutical Sciences》 |2012年第2期|共3页
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Ramesh Dhani; Rajesh K.; P. Mastanaiah;
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Synthesis and Physico-Chemical Analysis of 3-{[(3, 4-Dimethoxy-Phenyl)-Phenylamino-Methyl]-Amino}-2-Phenyl-Quinazolin-4(3h)-One

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