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首页> 外文期刊>Radiation oncology >Accelerated large volume irradiation with dynamic Jaw/Dynamic Couch Helical Tomotherapy
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Accelerated large volume irradiation with dynamic Jaw/Dynamic Couch Helical Tomotherapy

机译：动态颚/动态长沙发螺旋层析疗法加速大剂量照射

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Background Helical Tomotherapy (HT) has unique capacities for the radiotherapy of large and complicated target volumes. Next generation Dynamic Jaw/Dynamic Couch HT delivery promises faster treatments and reduced exposure of organs at risk due to a reduced dose penumbra. Methods Three challenging clinical situations were chosen for comparison between Regular HT delivery with a field width of 2.5 cm (Reg 2.5) and 5.0 cm (Reg 5.0) and DJDC delivery with a maximum field width of 5.0 cm (DJDC 5.0): Hemithoracic Irradiation, Whole Abdominal Irradiation (WAI) and Total Marrow Irradiation (TMI). For each setting, five CT data sets were chosen, and target coverage, conformity, integral dose, dose exposure of organs at risk (OAR) and treatment time were calculated. Results Both Reg 5.0 and DJDC 5.0 achieved a substantial reduction in treatment time while maintaining similar dose coverage. Treatment time could be reduced from 10:57 min to 3:42 min / 5:10 min (Reg 5.0 / DJDC 5.0) for Hemithoracic Irradiation, from 18:03 min to 8:02 min / 8:03 min for WAI and to 18:25 min / 18:03 min for TMI. In Hemithoracic Irradiation, OAR exposure was identical in all modalities. For WAI, Reg 2.5 resulted in lower exposure of liver and bone. DJDC plans showed a small but significant increase of ～ 1 Gy to the kidneys, the parotid glans and the thyroid gland. While Reg 5.0 and DJDC were identical in terms of OAR exposure, integral dose was substantially lower with DJDC, caused by a smaller dose penumbra. Conclusions Although not clinically available yet, next generation DJDC HT technique is efficient in improving the treatment time while maintaining comparable plan quality.
机译：背景螺旋断层扫描（HT）具有对大而复杂的目标体积进行放射治疗的独特能力。下一代Dynamic Jaw / Dynamic Couch HT的交付有望实现更快的治疗，并减少因半影剂量减少而有风险的器官。方法选择三种具有挑战性的临床情况，以比较视野宽2.5 cm（Reg 2.5）和5.0 cm（Reg 5.0）的常规HT递送和最大视野宽5.0 cm（DJDC 5.0）的DJDC递送：整个腹部辐照（WAI）和总骨髓辐照（TMI）。对于每种设置，选择了五个CT数据集，并计算了靶标覆盖率，一致性，整体剂量，高风险器官剂量（OAR）和治疗时间。结果Reg 5.0和DJDC 5.0都实现了治疗时间的大幅减少，同时保持了相似的剂量范围。对于半胸腔照射，治疗时间可以从10:57分钟减少到3:42分钟/ 5:10分钟（Reg 5.0 / DJDC 5.0），WAI从18:03分钟减少到8:02分钟/ 8:03分钟， TMI为18:25分钟/ 18:03分钟。在半胸腔照射中，所有方式的OAR暴露均相同。对于WAI，Reg 2.5可降低肝脏和骨骼的暴露。 DJDC计划显示肾脏，腮腺龟头和甲状腺的〜1 Gy小幅但显着增加。尽管Reg 5.0和DJDC在OAR暴露方面是相同的，但DJDC的积分剂量明显较低，这是因为半影剂量较小。结论尽管尚无临床可行的方法，但下一代DJDC HT技术可有效地缩短治疗时间，同时保持相当的计划质量。

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