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首页> 外文期刊>Reviews of Reproduction >The role of tight junction proteins in ovarian follicular development and ovarian cancer
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The role of tight junction proteins in ovarian follicular development and ovarian cancer

机译：紧密连接蛋白在卵巢滤泡发育和卵巢癌中的作用

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Tight junctions (TJ) are protein structures that control the transport of water, ions and macromolecules across cell layers. Functions of the transmembrane TJ protein, occluding (OCLN) and the cytoplasmic TJ proteins, tight junction protein 1 (TJP1; also known as zona occludens protein-1), cingulin (CGN) and claudins (CLDN) are reviewed, and current evidence of their role in the ovarian function is reviewed. Abundance of OCLN, CLDNs and TJP1 mRNA changed during follicular growth. In vitro treatment with various growth factors known to affect ovarian folliculogenesis indicated that CGN, OCLN and TJP1 are hormonally regulated. The summarized studies indicate that expression of TJ proteins (i.e., OCLN, CLDN, TJP1 and CGN) changes with follicle size in a variety of vertebrate species but whether these changes in TJ proteins are increased or decreased depends on species and cell type. Evidence indicates that autocrine, paracrine and endocrine regulators, such as fibroblast growth factor-9, epidermal growth factor, androgens, tumor necrosis factor-α and glucocorticoids may modulate these TJ proteins. Additional evidence presented indicates that TJ proteins may be involved in ovarian cancer development in addition to normal follicular and luteal development. A model is proposed suggesting that hormonal downregulation of TJ proteins during ovarian follicular development could reduce barrier function (i.e., selective permeability of molecules between theca and granulosa cells) and allow for an increase in the volume of follicular fluid as well as allow additional serum factors into the follicle that may directly impact granulosa cell functions.
机译：紧密连接（TJ）是蛋白质结构，可控制水，离子和大分子跨细胞层的运输。审查了跨膜TJ蛋白（OCLN）和细胞质TJ蛋白，紧密连接蛋白1（TJP1;也称为Zona occludens protein-1），调脂蛋白（CGN）和claudins（CLDN）的功能，并提出了最新证据审查了它们在卵巢功能中的作用。在卵泡生长过程中，OCLN，CLDNs和TJP1 mRNA的丰度发生了变化。用已知会影响卵巢卵泡形成的各种生长因子进行的体外治疗表明，CGN，OCLN和TJP1受激素调节。总结的研究表明，在各种脊椎动物中，TJ蛋白（即OCLN，CLDN，TJP1和CGN）的表达随卵泡大小的变化而变化，但是TJ蛋白的这些变化是增加还是减少取决于物种和细胞类型。有证据表明，自分泌，旁分泌和内分泌调节剂，例如成纤维细胞生长因子9，表皮生长因子，雄激素，肿瘤坏死因子α和糖皮质激素可能会调节这些TJ蛋白。提出的其他证据表明，除了正常的卵泡和黄体发育以外，TJ蛋白还可能参与卵巢癌的发展。提出了一个模型，表明卵巢卵泡发育过程中TJ蛋白的激素下调可能会降低屏障功能（即，卵泡膜和颗粒细胞之间分子的选择性通透性），并允许卵泡液体积增加以及其他血清因子进入卵泡可能直接影响颗粒细胞功能。

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