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首页> 外文期刊>Revista Colombiana de Ciencias Pecuarias >Efecto de dos niveles de dosis intravenosas de omeprazol sobre el pH del jugo gástrico de caballos sanos↓Efeito de dois níveis de doses intravenosas de omeprazol no suco gástrico pH cavalos saudáveis
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Efecto de dos niveles de dosis intravenosas de omeprazol sobre el pH del jugo gástrico de caballos sanos↓Efeito de dois níveis de doses intravenosas de omeprazol no suco gástrico pH cavalos saudáveis

机译：两种剂量的奥美拉唑静脉注射液对健康马胃液pH值的影响↓两种剂量的奥美拉唑非口服给药胃酸pH值对肠胃功能的影响

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Background: omeprazole suppresses gastric acid secretion and increases gastric juice pH by blocking the H+, K+ ATPase in the secretory membrane of parietal cells. Gastric juice pH below 4, long periods of no feed intake and stress are factors predisposing to gastric ulcers in horses. Objective: to determine the effect of 1 and 2 mg/Kg intravenous (IV) omeprazole on the gastric juice pH of Colombian Creole horses. Methods: seven horses were treated with two IV levels of omeprazole (1, and 2 mg/Kg body weight (BW)) in a crossover design. The omeprazole dose for each animal was reconstituted with 100 ml 0.9% NaCl. Gastric pH was measured using a portable pH-meter in stomach samples collected at time 0 (just before treatment), and 1, 2, 3, 5, 7, 9, 11, and 24 hours post-treatment. Results: the gastric pH at time 0 fluctuated from 1.6 to 3.2 in all horses. Both omeprazole doses (1 and 2 mg/Kg) significantly increased the gastric pH (pH>4.6) from 1 to 11 hours after the treatment. At 24 hours post-treatment, pH of the group treated with 1.0 mg/Kg significantly decreased to 2.8 ± 0.3, but remained elevated at 5.7 ± 0.87 for the group treated with 2 mg/Kg. Conclusion: the study demonstrated that a single IV omeprazole dose of 2 mg/Kg, but not 1 mg/Kg, maintained gastric pH above 4 during 24 hours.
机译：背景：奥美拉唑通过阻断壁细胞分泌膜中的H +，K + ATPase抑制胃酸分泌并增加胃液pH。胃液pH值低于4，长时间不进食和应激是导致马胃溃疡的因素。目的：确定1和2 mg / Kg静脉内（IV）奥美拉唑对哥伦比亚克里奥尔人马的胃液pH值的影响。方法：以交叉设计对7匹马进行两种IV水平的奥美拉唑治疗（分别为1和2 mg / Kg体重（BW））。用100 ml 0.9％NaCl重构每只动物的奥美拉唑剂量。使用便携式pH计在时间0（就在治疗前）以及治疗后1、2、3、5、7、9、11和24小时收集的胃样品中测量胃液pH。结果：所有马匹在0时的胃pH从1.6波动到3.2。两种奥美拉唑剂量（分别为1和2 mg / Kg）在治疗后1到11小时内均可显着提高胃的pH值（pH> 4.6）。在处理后24小时，用1.0mg / Kg处理的组的pH显着降低至2.8±0.3，但是对于用2mg / Kg处理的组，其pH仍保持在5.7±0.87。结论：该研究表明，单次IV奥美拉唑剂量为2 mg / Kg，而不是1 mg / Kg，可在24小时内将胃pH维持在4以上。

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