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首页> 外文期刊>Romanian Journal of Biophysics >PROTECTIVE ROLE OF GRAPE SEED EXTRACT AGAINST THE EFFECT OF BLUE LIGHT ON RETINA
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PROTECTIVE ROLE OF GRAPE SEED EXTRACT AGAINST THE EFFECT OF BLUE LIGHT ON RETINA

机译：葡萄籽提取物对蓝光对视网膜的保护作用

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The aim of the present study is to investigate the effect of blue light (403 nm) on electrorentinogram (ERG) and retinal rhodopsin. Also, the possible protective role of grape seed extract (GSE) was tested. Newzealand albino rabbits were used in this study. The rabbits exposed to blue light with and without GSE supplementation for 48 hours, one week, two weeks and 3 weeks respectively. At the end of each period, the electroretinogram (ERG) was recorded. The rabbit were decapitated; the rhodopsin was extracted, malondialdehyde (MDA), total antioxidant capacity (TAC) and fourier transform infrared spectrum (FTIR) of bleached rhodopsin was measured. The data indicates changes in ERG, MDA, TAC and FTIR spectra after blue light exposure. Supplementation of GSE improves the ERG parameters, leads to decrease MDA level and increase the TAC with respect to non supplemented antioxidant groups. It is concluded that long exposure to blue light affects retina and GSE may have protective effects that help in protecting the retina from blue light damage.
机译：本研究的目的是研究蓝光（403 nm）对脑电图（ERG）和视网膜视紫红质的影响。此外，还测试了葡萄籽提取物（GSE）的可能的保护作用。这项研究使用了新西兰白化兔。兔子分别在有和没有GSE的情况下暴露于蓝光下48小时，1周，2周和3周。在每个周期结束时，记录视网膜电图（ERG）。兔子被斩首。提取视紫红质，测定丙二醛（MDA），总抗氧化能力（TAC）和漂白视紫红质的傅里叶变换红外光谱（FTIR）。数据表明蓝光曝光后ERG，MDA，TAC和FTIR光谱的变化。相对于未添加的抗氧化剂基团，添加GSE可以改善ERG参数，降低MDA含量并增加TAC。结论是长时间暴露于蓝光会影响视网膜，GSE可能具有保护作用，有助于保护视网膜免受蓝光损害。

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