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首页> 外文期刊>Romanian Journal of Biophysics >CARBOHYDRATE-DEFICIENCE TRANSFERRIN AND GAMMA-GLUTAMYL TRANSPEPTIDASE-MARKERS OF EXCESSIVE ALCOHOL CONSUMPTION
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CARBOHYDRATE-DEFICIENCE TRANSFERRIN AND GAMMA-GLUTAMYL TRANSPEPTIDASE-MARKERS OF EXCESSIVE ALCOHOL CONSUMPTION

机译：过量摄入乙醇的碳水化合物不足的转铁蛋白和γ-谷氨酰转肽酶标记

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Carbohydrate-deficient transferrin (CDT) represents an important instrument for the evaluation process of alcohol consumption. But there is not a consensus on its use in the routine practice. The objective of this study was to compare carbohydrate-deficient transferrin and gamma-glutamyl transpeptidase (GGT) assays for the evaluation of alcohol consumption. 165 patients (100 male and 65 female) were included in this study. Patients were divided into five categories according to alcohol consumption: category 1 included non-weaned patients drinking more than 30 g/day for women and more than 50 g/day for men, category 2 included relapse patients, category 3 included moderate drinkers, category 4 included patients weaned less than one month, and category 5 included patients weaned more than one month. A specifically standardized questionnaire was used. Blood samples were drawn at the alcohol-cure outpatient centre. Samples were drawn at the first consultation and later as prescribed depending on the clinical situation. Sensitivity of CDT varied, depending on patient category, from 36% to 96% versus 45% to 70% for GGT. Specificity of CDT varied from 72% to 90% versus 21% to 61% for GGT. This study shows that carbohydrate-deficient transferrin is more accurate in predicting alcohol consumption compared with gamma-glutamyl transpeptidase in alcoholic patients evaluation.
机译：缺乏碳水化合物的转铁蛋白（CDT）是评估酒精消耗过程的重要工具。但是，在常规实践中仍未达成共识。这项研究的目的是比较缺乏碳水化合物的转铁蛋白和γ-谷氨酰转肽酶（GGT）测定法对酒精消耗的评估。这项研究包括165例患者（100例男性和65例女性）。根据酒精摄入量将患者分为五类：第一类包括非断奶患者，女性每天饮酒量超过30克/天，男性每天摄入50克/天以上;第二类包括复发患者，第三类包括中度饮酒者，第三类4名断奶不到一个月的患者，第5类断奶超过一个月的患者。使用了专门标准化的问卷。在戒酒门诊中心抽取血样。根据临床情况，在第一次会诊时抽取样本，随后按规定抽取样本。根据患者类别，CDT的敏感性从36％到96％不等，而GGT的敏感性从45％到70％不等。 CDT的特异性为72％至90％，而GGT为21％至61％。这项研究表明，在酒精饮料患者评估中，与γ-谷氨酰转肽酶相比，缺乏碳水化合物的转铁蛋白在预测酒精消耗方面更准确。

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