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首页> 外文期刊>Romanian Journal of Biophysics >RELATIONSHIP BETWEEN BRACHIAL ARTERY FLOW- MEDIATED DILATION AND CAROTID ARTERY INTIMA –MEDIA THICKNESS IN THE MIDDLE-AGED SUBJECTS WITH LOW CARDIOVASCULAR RISK
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RELATIONSHIP BETWEEN BRACHIAL ARTERY FLOW- MEDIATED DILATION AND CAROTID ARTERY INTIMA –MEDIA THICKNESS IN THE MIDDLE-AGED SUBJECTS WITH LOW CARDIOVASCULAR RISK

机译：心血管低风险中年受试者臂动脉血流介导的稀释与颈动脉内膜之间的关系

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Endothelial vasodilator dysfunction, assessed by brachial artery flow-mediated dilatation (FMD) and carotid intima-media thickening (IMT), is an indicator of subclinical atherosclerotic disease. We examined their correlation and interaction with traditionally cardiovascular risk factors, in a group of middle-aged subjects with a low total cardiovascular risk ( 50 mm Hg above systolic blood pressure (SBP), for 5 minutes. After the cuff was deflated ischemia – induced distal hyperemia produced a transient increase of artery diameter. The relative change in mean arterial diameter was calculated as: % Dilation = [Maximum diameter – Baseline diameter] × 100 / Baseline diameter, where maximum diameter was the maximum mean diameter observed at 45 – 60 seconds after cuff release. For carotid ultrasound study, the image was focused on the posterior (far) of the left carotid artery. A minimum of 4 measurements of the common carotid far wall were taken 10 mm proximal to the bifurcation to derive mean carotid IMT. Continuous variables are expressed as means ± SD. Means were compared using analysis of variance or the Student t-test. Our study shows that in a relatively healthy middle-aged subject, there is no significant correlation between carotid IMT and brachial artery FMD. This finding may be related to o temporal dissociation between functional and structural vascular abnormalities in a low risk population.
机译：通过肱动脉血流介导的扩张（FMD）和颈动脉内膜中层增厚（IMT）评估的内皮血管舒张功能障碍是亚临床动脉粥样硬化疾病的指标。在一组总心血管风险较低（高于收缩压（SBP）50 mm Hg）的中年受试者中，我们检查了它们与传统心血管危险因素的相关性和相互作用，持续了5分钟。远端充血引起动脉直径的短暂增加，平均动脉直径的相对变化计算如下：扩张百分比= [最大直径–基线直径]×100 /基线直径，其中最大直径是在45 – 60时观察到的最大平均直径松开袖带后的2秒钟内，进行颈动脉超声检查时，图像聚焦在左颈动脉的后部（远侧），在分叉处近10 mm处至少4次测量颈总动脉远壁，以得出平均颈动脉IMT 。连续变量表示为均值±标准差。使用方差分析或Student t检验比较均值。我们的研究表明，在相对健康的中年人中受试者中，颈动脉IMT与肱动脉FMD之间无显着相关性。这一发现可能与低危人群中功能性和结构性血管异常之间的暂时分离有关。

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