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首页> 外文期刊>Kurume Medical Journal >Histomorphological Investigation Regarding to Malignant Transformation of Pleomorphic Adenoma (So-called Malignant Mixed Tumor) of the Salivary Gland Origin: Special Reference to Carcinosarcoma
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Histomorphological Investigation Regarding to Malignant Transformation of Pleomorphic Adenoma (So-called Malignant Mixed Tumor) of the Salivary Gland Origin: Special Reference to Carcinosarcoma

机译：涎腺多形性腺瘤（所谓的恶性混合肿瘤）恶性转化的组织形态学研究：特别针对癌肉瘤

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Pleomorphic adenoma is the best-recognized tumor among those of salivary gland origin that also has the highest incidence. However, it is not uncommon for it to become malignant, and it has been noted that the frequency of malignancy increases as a result of the tumor persisting without being treated following the onset of adenoma. Carcinomatous components demonstrate various histological appearances, and in particular, there have been sporadic reports of carcinosarcoma in which malignant findings are not only observed in epithelial components, but in mesenchymal components as well. We conducted a histopathological study on cases of malignanttransformed pleomorphic adenoma, namely so-called malignant mixed tumor observed in our department. The subject cases consisted of a total of 19 cases registered in the diagnostic files of our department and included 12 males and 7 females. Age ranged from 46 to 87 (average 67.7) years old. The sites of occurrence consisted of the parotid gland in 17 cases, and palatal and buccal minor salivary glands in one case each. Histological types consisted of 7 cases of adenocarcinoma not otherwise specified, 3 cases of squamous cell carcinoma, 3 cases of salivary duct carcinoma, and one case each of polymorphous low-grade adenocarcinoma and epithelial-myoepithelial carcinoma, while the remaining were 2 cases of sarcomatoid carcinoma and 2 carcinosarcoma. We described herein their histological characteristics, discussed diagnostic problems in various instants in which each phenotype on this setting, and reviewed the literature, especially as to carcinosarcoma in contrast with those derived from other organs.
机译：多形性腺瘤是唾液腺来源的肿瘤中公认最好的肿瘤，其发病率也最高。然而，它变为恶性并不少见，并且已经注意到，由于肿瘤持续存在而没有在腺瘤发作后得到治疗，因此恶性肿瘤的频率增加。癌性成分表现出各种组织学表现，特别是，有零星的癌肉瘤报道，其中不仅在上皮成分中而且在间充质成分中也观察到恶性发现。我们对我科观察到的恶性转化的多形性腺瘤（即所谓的恶性混合瘤）进行了组织病理学研究。主题病例共19例，在我科诊断档案中登记，其中男12例，女7例。年龄从46岁到87岁（平均67.7岁）不等。发生部位包括腮腺17例，pa和颊小唾液腺各1例。组织学类型包括7例未另作说明的腺癌，3例鳞状细胞癌，3例唾液管癌，以及多形性低度腺癌和上皮-肌上皮癌各1例，其余为2例肉瘤癌和2癌肉瘤。我们在这里描述了它们的组织学特征，讨论了在这种情况下每种表型在不同时刻的诊断问题，并回顾了文献，尤其是与与其他器官衍生的癌肉瘤相反的癌肉瘤。

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