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首页> 外文期刊>Open Journal of Obstetrics and Gynecology >Immunohistochemical Analysis of p16 Expression in Uterine Smooth Muscle Tumors
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Immunohistochemical Analysis of p16 Expression in Uterine Smooth Muscle Tumors

机译：子宫平滑肌肿瘤中p16表达的免疫组织化学分析

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Objective: Immunohistochemistry with p16 antibody is used as a diagnostic marker in several gynecologic pathologies. The purpose of the present study was to evaluate the diagnostic and prognostic significance of p16 immunohistochemistry in various uterine smooth muscle tumors. Methods: Tissue specimens, including 29 leiomyomas, 13 smooth muscle tumors of uncertain malignant potential (STUMP), and 17 leiomyosarcomas, were obtained from 59 patients with uterine smooth muscle tumors. The prevalence of p16 expression in various uterine smooth muscle tumors was examined using immunohistochemistry methods and we investigated the association between p16 expression and various clinicopathologic parameters, including prognosis of leiomyosarcomas. Results: The prevalence of p16 expression of leiomyomas, STUMP, and leiomyosarcomas tumors was 10.3%, 38.4%, and 76.4%, respectively. The prevalence and immunohistochemistry scores of p16 were significantly higher in the leiomyosarcomas group than in the leiomyomas or STUMP tumor groups. In the leiomyosarcomas groups, p16 immunohistochemistry scores were significantly higher in the groups with more advanced stage, higher mitotic activity, and recurrence. The relationship among p16 immunohistochemistry scores and age, tumor size, extent of necrosis, and degree of myometrial invasion was not significant. High expression of p16 in leiomyosarcomas was linked to shorter disease-free and overall survival. Conclusions: The use of p16 immunohisitochemistry is a useful marker in differential diagnosis in various uterine smooth muscle tumors. Moreover, p16 overexpression possibly plays an important role in tumor progression and we demonstrate that p16 may be a predictor of overall survival in patients with leiomyosarcoma tumors.
机译：目的：p16抗体的免疫组织化学被用作几种妇科病理学的诊断标志物。本研究的目的是评估p16免疫组织化学在各种子宫平滑肌肿瘤中的诊断和预后意义。方法：从59例子宫平滑肌瘤患者中获得了29例平滑肌瘤，13例恶性潜能平滑肌瘤和17例平滑肌肉瘤的组织标本。使用免疫组织化学方法检查了各种子宫平滑肌肿瘤中p16表达的患病率，我们调查了p16表达与各种临床病理参数之间的关联，包括平滑肌肉瘤的预后。结果：平滑肌瘤，STUMP和平滑肌肉瘤的p16表达患病率分别为10.3％，38.4％和76.4％。平滑肌肉瘤组中p16的患病率和免疫组化评分明显高于平滑肌瘤或STUMP肿瘤组。在平滑肌肉瘤组中，p16免疫组化评分在晚期，有丝分裂活性和复发率更高的组中明显更高。 p16免疫组织化学评分与年龄，肿瘤大小，坏死程度和肌层浸润程度之间的关系不显着。 p16在平滑肌肉瘤中的高表达与较短的无病生存期和总生存期有关。结论：p16免疫组织化学的使用在各种子宫平滑肌肿瘤的鉴别诊断中是有用的标记。此外，p16的过表达可能在肿瘤进展中起重要作用，我们证明p16可能是平滑肌肉瘤患者总体生存的预测指标。

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